Specialized Services

Bioinformatics is a rapidly evolving field. Services provided by the Bioinformatics Core at Mayo Clinic are:

  • Single nucleotide polymorphism (SNP) selection for custom genotyping panels
  • Array-based differential gene expression
  • Next-generation sequencing data pre-processing, with workflows available for the characterization of:
    • Single nucleotide variants, indels, copy number alterations, translocations and inversions from whole-exome and whole-genome DNA sequencing (DNA-seq)
    • Gene expression, expressed single nucleotide variants, expressed indels, splice variants and fusion genes from RNA sequencing (RNA-seq)
    • MicroRNA expression from microRNA sequencing (miRNA-seq)
    • Methylation sites, transcription factor binding sites and chromatin modifications from methylation sequencing (methyl-seq) and ChIP sequencing (ChIP-seq)
  • Pacific Biosciences (PacBio) next-generation sequencing data pre-processing
  • Proteomics data pre-processing
  • Data annotation and pathways analysis
  • Assessment of internal and external omics data sets
  • Access to genotype, gene expression and methylation data from the Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO), the Genotype-Tissue Expression project (GTEx) and the Trans-Omics for Precision Medicine (TOPMed) programs of the National Institutes of Health (NIH

In addition to specialized services, the Bioinformatics Core at Mayo Clinic also offers concept and protocol design to help investigators design a study that tests their hypotheses.