A Study Of Organoids For Hypoxia-Induced Dysfunction In Hypertrophic Cardiomyopathy
Rochester, MN
The purpose of this study is to develop an in vitro cardiac organoid model representative of hypertrophic cardiomyopathy from myectomy-derived myocardial tissue. Investigate the impact of hypoxia on HCM pathophysiology and identify mechanisms driving differential susceptibility to hypoxia. Examine genotype-phenotype associations in HCM and sleep apnea susceptibility.