Detection of Biomarker in Chronic Rhinosinusitis Patients by Analyzing Nasal Sinus Secretions and Tissue via Endoscopic Sinus Surgery
The purpose of this study is to determine if there is a difference in baseline nasal KLK1 level in patients with chronic rhinosinusitis, with or without nasal polyposis, versus normal controls (as obtained via nasal lavage or suctioning of nasal secretions), if the baseline KLK1 level is correlated to tissue KLK1 level (obtained during endoscopic nasal sinus surgery), and if tissue or nasal KLK1 level is associated with clinical presentation and/or therapeutic outcomes.
A Study to Evaluate the Effect of Medical Intervention on Sinonasal Inflammation in Patients with Chronic Sinusitis, Nasal Polyps and Positive Sinus Culture
Jacksonville, FL; Scottsdale/Phoenix, AZ
The purpose of this study is to compare change in SNOT-22 score in patients who received medication therapy such as oral antibiotics, topical antibiotics, oral corticosteroids, topical corticosteroids, leukotriene receptor antagonist, and interleukin 5 receptor antagonist following endoscopic sinus surgery versus control in patient with chronic sinusitis with nasal polyps and a positive culture.
Outcomes of Positive Pressure Therapy for Obstructive Sleep Apnea Following Endoscopic Sinus Surgery
Rochester, MN; Scottsdale/Phoenix, AZ
The purpose of this study is to:
Evaluate if there are detrimental effects of restarting CPAP therapy on POD #0-1 in patients undergoing ESS compared to normal controls undergoing ESS without OSA.
Determine if there a difference in perception of pain and post-operative analgesia requirement in OSA patients restarting CPAP on POD #0-1 compared to non-OSA patients.
Determine if there are predictive factors for OSA patients undergoing ESS who require an overnight hospitalization after surgery.
Validate the nocturnal Rhinoconjuctivitis Quality ...