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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 13 for Amyotrophic lateral sclerosis (ALS)

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  • Study status: Open/Status Unknown
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  1. A Study to Evaluate MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients with Amyotrophic Lateral Sclerosis (ALS)

    Jacksonville, FL

  2. A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adults With Amyotrophic Lateral Sclerosis

    Jacksonville, FL

  3. A Study to Evaluate the Effectiveness, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB067 Administered to Adult Subjects with Amyotrophic Lateral Sclerosis and Confirmed Superoxide Dismutase 1 Mutation

    Jacksonville, FL, Rochester, MN

  4. Perampanel Transcranial Magnetic Stimulation (TMS) in Amyotrophic Lateral Sclerosis (ALS)

    Jacksonville, FL

  5. A Study to Evaluate the Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS

    Jacksonville, FL

  6. Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS)

    Rochester, MN, Scottsdale/Phoenix, AZ, Jacksonville, FL

  7. A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis

    Jacksonville, FL

  8. Immune Phenotyping in Amyotrophic Lateral Sclerosis

    Rochester, MN

  9. Blood and Spinal Fluid Collection for Research Studies in Motor Neuron Disease and Motor Neuropathy

    Rochester, MN

  10. Biospecimen Collection to Investigate the Causes of ALS

    Jacksonville, FL

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