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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 10 for Amyotrophic lateral sclerosis (ALS)

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  • Study status: Open/Status Unknown
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  1. HEALEY ALS Platform Trial

    Jacksonville, FL, Rochester, MN

  2. A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 in Amyotrophic Lateral Sclerosis (ALS) Patients

    Jacksonville, FL

  3. A Study to Evaluate MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients with Amyotrophic Lateral Sclerosis (ALS)

    Jacksonville, FL, Rochester, MN

  4. A Study to Determine the Effectiveness and Safety of Oral Edaravone Administered in Subjects with Amyotrophic Lateral Sclerosis

    Jacksonville, FL, Rochester, MN

  5. A Study to Evaluate Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis

    Rochester, MN, Scottsdale/Phoenix, AZ, Jacksonville, FL

  6. Immune Phenotyping in Amyotrophic Lateral Sclerosis

    Rochester, MN

  7. Blood and Spinal Fluid Collection for Research Studies in Motor Neuron Disease and Motor Neuropathy

    Rochester, MN

  8. Radicava® (Edaravone) Biomarker Study in Participants with Amyotrophic Lateral Sclerosis

    Jacksonville, FL

  9. DNA, Blood, and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida

    Jacksonville, FL

  10. A Study to Gather Patient Views on Informed Consent for ALS Trial

    Rochester, MN

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