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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 11-15 of 15 for Heart valve disease

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  • Study status: Open/Status Unknown
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  1. Usefulness of Color M-mode for Vena Contracta of Aortic Regurgitation in Patients with Left Ventricular Assist Devices

    Rochester, MN

  2. A Repository of Atria Tissue for the Investigation of Atrial Pathophysiology in Patients with Atrial Fibrillation

    Rochester, MN

  3. A Study to Collect Serum Samples from Patients Presenting for Aortic Valve Replacement

    Rochester, MN

  4. Invasive Hemodynamic Response to Transcatheter Edge-to-Edge Mitral Valve Repair

    Rochester, MN

  5. Comprehensive Imaging and Biomarker Assessment of Aortic Valve Stenosis

    Rochester, MN


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