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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 11-20 of 23 for Atrial fibrillation

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  • Study status: Open/Status Unknown
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  1. A Trial Comparing Left Atrial Appendage Occlusion Therapy to Non-Vitamin K Oral Anticoagulants in Atrial Fibrilation Patients

    Rochester, MN

  2. A Study to Determine if Identification of Undiagnosed Atrial Fibrillation in People at Least 70 Years of Age Reduces the Risk of Stroke

    Jacksonville, FL

  3. A Study to Evaluate the Effectiveness and Safety of Remdesivir to Treat Coronavirus Disease 2019 in an Outpatient Setting

    Rochester, MN

  4. A Study to Identify the Self-Sustaining Core Causing Atrial Fibrillation, by Using Electrograms of Atrial and Ventricular Fibrillation to Calculate Wave Changes as Contractions Pass Through the Heart Muscle

    Scottsdale/Phoenix, AZ, Rochester, MN

  5. A Study of Aortic Valve Gradient Severity in Patients with Atrial Fibrillation

    Rochester, MN

  6. A Study to Analyze Association of Frequent Premature Ventricular Complex with Stroke or Transient Ischemic Attack

    Rochester, MN

  7. A Study to Analyze Arterial Stiffness and Atrial Fibrillation

    Rochester, MN

  8. A Repository of Atria Tissue for the Investigation of Atrial Pathophysiology in Patients with Atrial Fibrillation

    Rochester, MN

  9. A Study to Assess Aortic Valve Severity in Patients with Atrial Fibrillation Pre and Post Cardioversion

    Rochester, MN

  10. A Study to Evaluate Catheter Ablation Outcomes in Athletes with Atrial Fibrillation

    Scottsdale/Phoenix, AZ


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