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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 11-20 of 103 for Brain tumor

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  1. A Study of FT 2102 in Participants with Advanced Solid Tumors and Gliomas with an IDH1 Mutation

    Jacksonville, FL

  2. A Study of ONC201 for Patients with H3 K27M-mutant and/or Midline High Grade Gliomas

    Jacksonville, FL, Rochester, MN

  3. A Study to Evaluate the Safety and Tolerability of DCC-2618 in Patients with Advanced Malignancies

    Jacksonville, FL

  4. A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Anti-tumor Activity of WSD0922-FU

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  5. A Study to Evaluate Veliparib, Radiation Therapy, and Temozolomide in Treating Participants with Newly Diagnosed Malignant Glioma without H3 K27M or BRAFV600 Mutations

    Rochester, MN

  6. Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

    Jacksonville, FL, Rochester, MN

  7. Safety Study of VAL-083 in Patients with Recurrent Malignant Glioma

    Rochester, MN

  8. Investigating Dysregulation of the Glutamatergic System using High Frequency Oscillations (HFOs) in Glioma Related-Seizures

    Jacksonville, FL

  9. Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

    Rochester, MN

  10. A Study to Evaluate a Standard-dose and High- dose Regimen of Encorafenib + Binimetinib in Patients with BRAFV600-mutant Melanoma Brain Metastasis

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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