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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

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  1. Colorectal Cancer Screening in Black and Underserved Communities in the Phoenix Metro Area

    Scottsdale/Phoenix, AZ

  2. Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis

    Rochester, MN

  3. Study to Assess the Safety of the Temporarily Implanted Nitinol Device Compared to the Urolift® System in Subjects With Symptomatic Benign Prostatic Hyperplasia

    Scottsdale/Phoenix, AZ

  4. A Study of Ranolazine in ALS

    Jacksonville, FL

  5. Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer

    Jacksonville, FL, Rochester, MN, Scottsdale/Phoenix, AZ

  6. Study to Improve health-related quality of life (HRQOL) in Black Prostate Cancer Patients (CaPQoL) through Whole Person Survivorship Care

    Jacksonville, FL

  7. Lasofoxifene and Abemaciclib to the Combination of Fulvestrant and Abemaciclib for Locally Advanced or Metastatic ER+/HER2− Breast Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  8. Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  9. SRG-514 Administered Intraoperatively to Patients Undergoing Breast-conserving Cancer Surgery

    Rochester, MN

  10. mHealth App for Caregiver Instructino for Chemotherapy-Induced Peripheral Neuropathy

    Jacksonville, FL

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