Clinical Trials

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Scottsdale/Phoenix, AZ, Rochester, MN

See Details

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
3
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

This randomized phase II clinical trial studies how well nivolumab after combined modality therapy works in treating patients with high risk stage II-IIIB anal cancer. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Closed for enrollment	View complete study & contact information
Scottsdale/Phoenix, Ariz.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 18-004936
- Scottsdale/Phoenix, Arizona: 18-004936
NCT ID:
NCT03233711
Sponsor Protocol Number:
EA2165

Study Evaluating the Safety and Efficacy of Fenfluramine Hydrochloride Oral Solution (ZX008)as Adjunctive Therapy in Children with Intractable Epilepsy with Myoclonic-Atonic Seizures

Rochester, MN

See Details

Study Evaluating the Safety and Efficacy of Fenfluramine Hydrochloride Oral Solution (ZX008)as Adjunctive Therapy in Children with Intractable Epilepsy with Myoclonic-Atonic Seizures

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to document the effectiveness of ZX008 as adjunctive therapy by documenting percent reduction in convulsive seizures and drop seizures in subjects taking ZX008compared to baseline.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 17-004023
Sponsor Protocol Number:
17-004023

Study of the Preceptis Medical Inc. Hummingbird™ Tympanostomy Tube System in the Otolaryngology Clinic

Rochester, MN

See Details

Study of the Preceptis Medical Inc. Hummingbird™ Tympanostomy Tube System in the Otolaryngology Clinic

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The objective of this study is to evaluate the safety and performance of the H-TTS for the placement of ear tubes in patients undergoing tympanostomy tube placement in an otolaryngology clinic using local anesthetic.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 18-003212
NCT ID:
NCT03544138
Sponsor Protocol Number:
NCT03544138

A Study to Evaluate the Safety, Effectiveness, and Tolerability of Latiglutenase to Treat Patients with Well-Controlled Celiac Disease

Rochester, MN

See Details

A Study to Evaluate the Safety, Effectiveness, and Tolerability of Latiglutenase to Treat Patients with Well-Controlled Celiac Disease

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
2
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The purpose of this study is to demonstrate a positive correlation of histologic protection (biological signature) and symptom protection (clinical outcome) for latiglutenase treatment versus placebo in Celiac Disease (CD) patients undergoing a deliberate gluten challenge.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 17-005351
NCT ID:
NCT03585478
Sponsor Protocol Number:
IMGX003-NCCIH-1721

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients with Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorder

Rochester, MN

See Details

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients with Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorder

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
2
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The purpose of this Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 18-000708
NCT ID:
NCT03155620
Sponsor Protocol Number:
APEC1621SC

Intraocular Pressure in Ocular Hypertensives with Scleral Lens Wear

Rochester, MN

See Details

Intraocular Pressure in Ocular Hypertensives with Scleral Lens Wear

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to determine if short-term wear of a scleral contact lens will raise intraocular pressure in ocular hypertensive patients.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 18-004974
NCT ID:
NCT04442464
Sponsor Protocol Number:
18-004974

Using Ice Around Postoperative Total Knee Incisions – Does This Make Sense?

See Details

Reverse Total Shoulder Arthroplasty versus Nonoperative Treatment of 3 & 4-Part Proximal Humerus Fractures

Rochester, MN

See Details

Reverse Total Shoulder Arthroplasty versus Nonoperative Treatment of 3 & 4-Part Proximal Humerus Fractures

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

This purpose of this study is to answer if patients fair better with non-operative management or reverse total arthroplasty for treatment of 3- and 4-part proximal humerus fractures.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 18-002097
NCT ID:
NCT03599336
Sponsor Protocol Number:
18-002097

A Study to Understand the Mechanisms of Normal and Disordered Defection

Rochester, MN

See Details

A Study to Understand the Mechanisms of Normal and Disordered Defection

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to compare rectal emptying and rectoanal pressures in healthy people and DD. Our hypotheses are that (i) the rate and amount of rectal emptying is higher in healthy people than in patients with DD, (ii) some patients with symptoms of DD will have a normal balloon expulsion test but reduced rectal emptying measured with fecomanoflowmetry, and (iii) compared to healthy people, the rectal pressure increment and/or anal relaxation is reduced in patients with DD.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 18-010327
NCT ID:
NCT03842007
Sponsor Protocol Number:
18-010327

Study to Create a Registry to Collect the Findings and Outcomes of Patients Undergoing Contrast-Enhanced Harmonic Endoscopic Ultrasound (CE-EUS)

Jacksonville, FL

See Details

Study to Create a Registry to Collect the Findings and Outcomes of Patients Undergoing Contrast-Enhanced Harmonic Endoscopic Ultrasound (CE-EUS)

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to describe the findings and outcomes of patient undergoing contrast-enhanced harmonic endoscopic ultrasound (CE-EUS) imaging. A registry will be created to monitor for possible procedure adverse events and to perform descriptive statistics for the patients who undergo this procedure.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, Fla.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Jacksonville, Florida: 18-008737
Sponsor Protocol Number:
18-008737

Filter Results

Locations

Study status

Gender

Age

Healthy Volunteer

Study phase

Search Results 1941-1950 of 10650

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Study Evaluating the Safety and Efficacy of Fenfluramine Hydrochloride Oral Solution (ZX008)as Adjunctive Therapy in Children with Intractable Epilepsy with Myoclonic-Atonic Seizures

Study of the Preceptis Medical Inc. Hummingbird™ Tympanostomy Tube System in the Otolaryngology Clinic

A Study to Evaluate the Safety, Effectiveness, and Tolerability of Latiglutenase to Treat Patients with Well-Controlled Celiac Disease

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients with Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorder

Intraocular Pressure in Ocular Hypertensives with Scleral Lens Wear

Using Ice Around Postoperative Total Knee Incisions – Does This Make Sense?

Reverse Total Shoulder Arthroplasty versus Nonoperative Treatment of 3 & 4-Part Proximal Humerus Fractures

A Study to Understand the Mechanisms of Normal and Disordered Defection

Study to Create a Registry to Collect the Findings and Outcomes of Patients Undergoing Contrast-Enhanced Harmonic Endoscopic Ultrasound (CE-EUS)

Mayo Clinic Footer

Legal Conditions and Terms

Advertising

Reprint Permissions