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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 5261-5270 of 10988

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  1. Role of Sound Source Location on Directional Microphone Benefit in Adult Cochlear Implant Recipients

    Rochester, MN

  2. Review of the Safety and Effectiveness of the THERMOCOOL SMARTTOUCH® SF Catheter Evaluated for Treating Symptomatic PersistenT AF (PRECEPT)

  3. A Study of ACP-196 Alone and in Combination with Pembrolizumab in Subjects with Advanced or Metastatic Pancreatic Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  4. Reliability of Measurements of Ankle Joint Dorsiflexion Using a Weight-Bearing Lunge Test Obtained in a Clinical Setting

    Rochester, MN

  5. Muscle and Adipose Trafficking of Fatty Acids Under Hypoinsulinemic and Fed Conditions

  6. A Study of the Safety and Effectiveness of Combined Toca 511 and Toca FC for Patients Having Removal Surgery for Recurring Glioblastoma or Anaaplastic Astrocytoma

    Jacksonville, FL

  7. A Study to Determine if Early Changes of Pulmonary Artery Hypertension can be Seen by Adding Exercise During Cardiac Magnetic Resonance Imaging (MRI)

    Jacksonville, FL

  8. A Study of the Effect of Vedolizumab in Conjunction with Structured Semi-Vegetarian Diet on the Treatment of Ulcerative Colitis

    Jacksonville, FL

  9. Mechanical Ventilation Guided By Transpulmonary and Airway Driving Pressures

    Rochester, MN

  10. Olanzapine for the Treatment of Chronic Nausea and/or Vomiting in Advanced Cancer Patients

    Rochester, MN

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