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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 6471-6480 of 11532

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  1. A Study of Transcutaneous and Epidural Spinal Stimulation for Enabling Motor Function in Humans with Motor Complete Paraplegia

    Rochester, MN

  2. A Study of the Effectiveness of a Stabilization Exercise Program for Thumb Carpometacarpal Degenerative Joint Disease

    Jacksonville, FL

  3. A Study to Investigate the Effectiveness and Safety of Pf-04965842 in Subjects Aged 12 Years and Over, With Moderate to Severe Atopic Dermatitis with the Option of Rescue Treatment in Flaring Subjects

    Rochester, MN

  4. Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients with Newly Diagnosed Ependymoma

    Rochester, MN

  5. Intense Pulsed Light (IPL) and Meibomian Gland Expression to Treat Ocular Rosacea Secondary to Inactive Chronic Ocular GVHD

    Scottsdale/Phoenix, AZ

  6. Phase 1/2 Dose Escalation and Efficacy Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies

    Scottsdale/Phoenix, AZ, Rochester, MN

  7. Panobinostat in Treating Patients with Relapsed or Refractory Non-Hodgkin Lymphoma

    Rochester, MN

  8. Comparison of Different Types of Surgery in Treating Patients with Stage IA Non-Small Cell Lung Cancer

    Rochester, MN

  9. Gene Therapy and Radioactive Iodine in Treating Patients with Locally Recurrent Prostate Cancer that Did Not Respond to External-Beam Radiation Therapy

    Rochester, MN

  10. Rituximab, Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients with Relapsed or Refractory Low-Grade Follicular Lymphoma, Waldenstrom Macroglobulinemia, or Mantle Cell Lymphoma

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