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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

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  1. High-Intensity Aerobic Interval Training in Early Outpatient Cardiac Rehabilitation

    Rochester, MN

  2. A Study of Stress Management Intervention in a Women's Heart Clinic, The Heart SMART Program

    Rochester, MN

  3. A Study to Evaluate the Safety and Effectiveness of the Multi-Electrode Radiofrequency Balloon Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation

  4. A Study to Evaluate Injectafer® as Treatment for Heart Failure with Iron Deficiency

    Rochester, MN

  5. A Study to Understand How Feedback from Breathing Muscles Influence Blood Flow and Blood Pressure during Exercise and if this can Reduce a Response in Heart Failure Patients with Breathing Muscle Training

    Rochester, MN

  6. A Study to Determine the Impact of Patient-Centered Education and the Use of Digital Photography for Evaluating Adherence with Routine Foot Care and Decrease the Occurrence and Severity of Foot Ulcerations in High-Risk Diabetic Foot Patients

    Scottsdale/Phoenix, AZ

  7. A Study to Assess the Safety and Tolerability of Atezolizumab in Combination With Other Immune-Modulating Therapies in Participants With Locally Advanced or Metastatic Solid Tumors

  8. A Study to Evaluate the Effectiveness of Nicotinamide Riboside and Pterostilbene Treatment to Protect the Kidneys in Patients with Complex Aortic Aneurysm Repair and Aortic Arch Reconstruction

    Rochester, MN

  9. A Study of RoActemra/Actemra (Tocilizumab) in Comparison to Etanercept in Patients With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

    Rochester, MN

  10. A Study to Determine Effectiveness of Perioperative Smoking Cessation in Surgical Patients Using Short Messaging Service Program

    Rochester, MN

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