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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 81-90 of 833 for cardiovascular

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  1. Nicotinamide Riboside Supplementation and Aging on Altitude Acclimatization

    Scottsdale/Phoenix, AZ

  2. A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

    Jacksonville, FL

  3. Extravascular ICD Pivotal Study

    Rochester, MN

  4. Donor After Circulatory Death Heart CAP Trial

    Jacksonville, FL

  5. ABSORB III Randomized Controlled Trial (RCT)

    Rochester, MN

  6. An Efficacy, Safety and Tolerability Study of Ixmyelocel-T Administered via Transendocardial Catheter-based Injections to Subjects with Heart Failure Due to Ischemic Dilated Cardiomyopathy (IDCM)

    Scottsdale/Phoenix, AZ

  7. Respiratory Muscle Contribution to Blood Pressure During Exercise

    Rochester, MN

  8. Improving Cardiac Rehabilitation Outcomes Through Mobile Case Management (iCARE)

    Rochester, MN

  9. Vascular Boot Warming Program After Acute Deep Vein Thrombosis (DVT) ± Pulmonary Embolism (PE)

  10. Effect of RBT-1 on Preconditioning Response Biomarkers in Subjects Undergoing CABG and/or Cardiac Valve Surgery

    Rochester, MN

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