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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 221-230 of 836 for cardiovascular

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  1. Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

    Rochester, MN

  2. High-Intensity Aerobic Interval Training in Early Outpatient Cardiac Rehabilitation

    Rochester, MN

  3. A Study to Evaluate the Safety and Effectiveness of the Multi-Electrode Radiofrequency Balloon Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation

  4. A Study to Evaluate Injectafer® as Treatment for Heart Failure with Iron Deficiency

    Rochester, MN

  5. A Study of the Best Position for the Passive Driver (Vibration Transmitter) in Cardiac Magnetic Resonance Elastography (MRE)

    Rochester, MN

  6. A Study to Evaluate the Effectiveness of Vacuum-Assisted Dressings for the Management of Open Chest Wounds

    Jacksonville, FL

  7. Physiologic Effects of Sleep Restriction

    Rochester, MN

  8. A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure

    Jacksonville, FL

  9. Clinical Evaluation of the CADence Device in Detection of Coronary Artery Diseases

    Rochester, MN

  10. Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction

    Rochester, MN

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