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Cisplatin With Or Without Veliparib In Treating Patients With Recurrent Or Metastatic Triple-Negative And/or BRCA Mutation-Associated Breast Cancer With Or Without Brain Metastases

Eau Claire, WI, La Crosse, WI, Rochester, MN

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Cisplatin With Or Without Veliparib In Treating Patients With Recurrent Or Metastatic Triple-Negative And/or BRCA Mutation-Associated Breast Cancer With Or Without Brain Metastases

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
2
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

This randomized phase II trial studies how well cisplatin works with or without veliparib in treating patients with triple-negative breast cancer and/or BRCA mutation-associated breast cancer that has come back or has or has not spread to the brain. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known if cisplatin is more effective with or without veliparib in treating patients with triple-negative and/or BRCA mutation-associated breast cancer.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Eau Claire, WI	Closed for enrollment	View complete study & contact information
La Crosse, WI	Closed for enrollment
Rochester, MN	Closed for enrollment

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Site IRB:
16-009577
NCT ID:
NCT02595905
Sponsor Protocol Number:
S1416

A Study To Evaluate At Home Administration Of Pertuzumab Combined With Trastuzumab To Treat Patients With HER2-Positive Breast Cancer During COVID-19 Pandemic

Jacksonville, FL, Rochester, MN

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A Study To Evaluate At Home Administration Of Pertuzumab Combined With Trastuzumab To Treat Patients With HER2-Positive Breast Cancer During COVID-19 Pandemic

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to assess the safety of PH FDC SC when administered at home by an HHNP. Patients will be assessed for safety by regular evaluation of AEs, vital signs, routine clinical laboratory tests (hematology, blood chemistry), LVEF assessments, and by physical examinations.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Closed-enrolling by invitation What is this? (?)	View complete study & contact information
Rochester, MN	Closed-enrolling by invitation What is this? (?)

Mayo Clinic Location

Status

Contact

Jacksonville, FL

Closed-enrolling by invitation

View complete study & contact information

Rochester, MN

Closed-enrolling by invitation

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Site IRB:
21-001748
NCT ID:
NCT04395508
Sponsor Protocol Number:
AL42478

A Randomized Phase III Trial Of Eribulin Compared To Standard Weekly Paclitaxel As First- Or Second-Line Therapy For Locally Recurrent Or Metastatic Breast Cancer

Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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A Randomized Phase III Trial Of Eribulin Compared To Standard Weekly Paclitaxel As First- Or Second-Line Therapy For Locally Recurrent Or Metastatic Breast Cancer

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
3
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

This is a two arm Phase III trial in first and second-line HER2 negative patients with locally recurrent or metastatic breast cancer. The primary endpoint is overall survival (OS), and the objective is to test for the superiority of eribulin mesylate over standard weekly paclitaxel. Patients will be randomized between the experimental and control arm with equal allocation (1:1) within strata defined by prior adjuvant taxanes, hormone receptor status, and line of therapy. Subjects will continue protocol directed therapy until documentation of disease progression, development of unacceptable toxicity, or withdrawal of consent. Those who discontinue study treatment without radiological progression will be followed with repeat imaging studies every 12 weeks. All subjects will be followed until death, withdrawal of consent, or study termination.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, AZ	Closed for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment
Rochester, MN	Closed for enrollment

Print study details

Site IRB:
13-002454
NCT ID:
NCT02037529
Sponsor Protocol Number:
RU011201I

A Study Of To Evaluate Palbociclib In Combination With Letrozole And Trastuzumab In Stage II-III ER+ HER2+ Breast Cancer

Scottsdale/Phoenix, AZ
- See Details
A Study Of To Evaluate Palbociclib In Combination With Letrozole And Trastuzumab In Stage II-III ER+ HER2+ Breast Cancer
- Study type:
  Interventional
  Describes the nature of a clinical study. Types include:
  
  Observational study — observes people and measures outcomes without affecting results.
  
  Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
  
  Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Study phase:
  2
  During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study

The purpose of this study is to evaluate combining endocrine therapy with CDK4/6 inhibition along with trastuzumab in ER+/ human epidermal growth factor receptor 2 (HER2)+ early stage breast cancer in order to influence estrogen receptor (ER) signaling.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, AZ

Closed for enrollment
View complete study & contact information

Print study details
Site IRB:
18-011037

NCT ID:
NCT02907918

Sponsor Protocol Number:
201610019
A Study Of Afatinib Treatment For Patients With Epidermal Growth Factor Receptor Mutation Positive Non-Small Cell Lung Cancer, Who Are Age 70 Or Older

Scottsdale/Phoenix, AZ
- See Details
A Study Of Afatinib Treatment For Patients With Epidermal Growth Factor Receptor Mutation Positive Non-Small Cell Lung Cancer, Who Are Age 70 Or Older
- Study type:
  Interventional
  Describes the nature of a clinical study. Types include:
  
  Observational study — observes people and measures outcomes without affecting results.
  
  Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
  
  Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Study phase:
  4
  During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study

The purpose of this study is to describe the occurence of adverse events which lead to the reduction in dose of afatinib in elderly patients with non-small cell lung cancer, who have common EGFR (epidermal growth factor receptor) mutations.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, AZ

Closed for enrollment
View complete study & contact information

Print study details
Site IRB:
15-006154

NCT ID:
NCT02514174

Sponsor Protocol Number:
1200.209

Understanding Challenges, Behavioral Patterns, And Preferences Toward Participation In Clinical Trials In Minority Patient Populations: Development Of A Personalized Clinical Trial Educational Platform To Increase Participation In Clinical Trials Among Underserved Cancer Patients

Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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Understanding Challenges, Behavioral Patterns, And Preferences Toward Participation In Clinical Trials In Minority Patient Populations: Development Of A Personalized Clinical Trial Educational Platform To Increase Participation In Clinical Trials Among Underserved Cancer Patients

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

This clinical trial investigates the challenges, behavioral patterns, and preferences towards participation in clinical trials in minority patient populations in order to develop a personalized clinical trial educational platform to increase participation in clinical trials among underserved cancer patients. Learning more about patients' understanding of clinical trials may help identify barriers that limit patient's participation. Information gathered from this trial will be used to develop educational materials that may aid minority patients in overcoming barriers to participating in clinical trials. A personalized clinical trial educational platform may help increase participation in clinical trials among minority populations.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, AZ	Closed for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment
Rochester, MN	Closed for enrollment

Print study details

Site IRB:
19-004014
NCT ID:
NCT04630431
Sponsor Protocol Number:
MC220901

A Study To Evaluate Decreasing Chemotherapy For Breast Cancer Patients After Pre-surgery Chemo And Targeted Therapy

Eau Claire, WI, La Crosse, WI, Rochester, MN

See Details

A Study To Evaluate Decreasing Chemotherapy For Breast Cancer Patients After Pre-surgery Chemo And Targeted Therapy

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
2
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Trastuzumab and pertuzumab are both a form of "targeted therapy" because they work by attaching themselves to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When these drugs attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving paclitaxel, trastuzumab, and pertuzumab may enable fewer chemotherapy drugs to be given without compromising patient outcomes compared to the usual treatment.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Eau Claire, WI	Closed for enrollment	View complete study & contact information
La Crosse, WI	Closed for enrollment
Rochester, MN	Closed for enrollment

Print study details

Site IRB:
20-004567
NCT ID:
NCT04266249
Sponsor Protocol Number:
EA1181

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

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Search Results 851-860 of 1772 for cancer

Cisplatin With Or Without Veliparib In Treating Patients With Recurrent Or Metastatic Triple-Negative And/or BRCA Mutation-Associated Breast Cancer With Or Without Brain Metastases

A Study To Evaluate At Home Administration Of Pertuzumab Combined With Trastuzumab To Treat Patients With HER2-Positive Breast Cancer During COVID-19 Pandemic

A Randomized Phase III Trial Of Eribulin Compared To Standard Weekly Paclitaxel As First- Or Second-Line Therapy For Locally Recurrent Or Metastatic Breast Cancer

A Study Of To Evaluate Palbociclib In Combination With Letrozole And Trastuzumab In Stage II-III ER+ HER2+ Breast Cancer

A Study Of Afatinib Treatment For Patients With Epidermal Growth Factor Receptor Mutation Positive Non-Small Cell Lung Cancer, Who Are Age 70 Or Older

Understanding Challenges, Behavioral Patterns, And Preferences Toward Participation In Clinical Trials In Minority Patient Populations: Development Of A Personalized Clinical Trial Educational Platform To Increase Participation In Clinical Trials Among Underserved Cancer Patients

A Study To Evaluate Decreasing Chemotherapy For Breast Cancer Patients After Pre-surgery Chemo And Targeted Therapy

Veliparib With Carboplatin And Paclitaxel And As Continuation Maintenance Therapy In Subjects With Newly Diagnosed Stage III Or IV, High-grade Serous, Epithelial Ovarian, Fallopian Tube, Or Primary Peritoneal Cancer

A Study To Evaluate The Combination Of Binimetinib And Palbociclib In Treating Patients With KRAS And NRAS Mutant Metastatic Or Unresectable Colorectal Cancer

Vaccine Therapy In Treating Patients With Stage IIIC-IV Ovarian Epithelial, Fallopian Tube, Or Primary Peritoneal Cavity Cancer Following Surgery And Chemotherapy

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