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Evaluating Changes In Quality Of Life After Near Margin-less Adaptive Radiation Therapy Compared To Standard Stereotactic Ablative Body Radiotherapy In Localized Prostate Cancer

Albert Lea, MN, Eau Claire, WI, La Crosse, WI, Mankato, MN, Rochester, MN

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Evaluating Changes In Quality Of Life After Near Margin-less Adaptive Radiation Therapy Compared To Standard Stereotactic Ablative Body Radiotherapy In Localized Prostate Cancer

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to assess treatment-related, patient-reported early QOL changes after stereotactic ablative body radiotherapy (SABR) using the EPIC-26 bowel and bladder domains.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Albert Lea, MN	Open for enrollment	View complete study & contact information
Eau Claire, WI	Open for enrollment
La Crosse, WI	Open for enrollment
Mankato, MN	Open for enrollment
Rochester, MN	Open for enrollment

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Site IRB:
23-003388
NCT ID:
NCT06325046
Sponsor Protocol Number:
GMROR2351

Assessment Of The Efficacy And Safety Of Olaparib Monotherapy Versus Physicians Choice Chemotherapy In The Treatment Of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.

Jacksonville, FL, Rochester, MN
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Assessment Of The Efficacy And Safety Of Olaparib Monotherapy Versus Physicians Choice Chemotherapy In The Treatment Of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.
- Study type:
  Interventional
  Describes the nature of a clinical study. Types include:
  
  Observational study — observes people and measures outcomes without affecting results.
  
  Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
  
  Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Study phase:
  3
  During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study

This open label, randomised, controlled, multi-centre phase III study will assess the efficacy and safety of single agent olaparib vs standard of care based on physician's choice of capecitabine, vinorelbine or eribulin in metastatic breast cancer patients with gBRCA 1/2 mutations.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Jacksonville, FL

Closed for enrollment
View complete study & contact information

Rochester, MN

Closed for enrollment

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Site IRB:
14-001087

NCT ID:
NCT02000622

Sponsor Protocol Number:
D0819C00003

Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer

Jacksonville, FL, Scottsdale/Phoenix, AZ, Rochester, MN

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Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
3
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

This randomized phase III trial studies oxaliplatin, leucovorin calcium, fluorouracil, and bevacizumab to see how well they work compared to oxaliplatin, leucovorin calcium, and fluorouracil in treating patients who have undergone surgery for stage II colon cancer. Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. It is not yet known whether giving combination chemotherapy together with bevacizumab is more effective than combination chemotherapy alone in treating colon cancer.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Closed for enrollment	View complete study & contact information
Scottsdale/Phoenix, AZ	Closed for enrollment
Rochester, MN	Closed for enrollment

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Site IRB:
4-06
NCT ID:
NCT00217737
Sponsor Protocol Number:
E5202

A Study Of Atezolizumab Plus Carboplatin And Etoposide With Or Without Tiragolumab In Patients With Untreated Extensive-Stage Small Cell Lung Cancer

Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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A Study Of Atezolizumab Plus Carboplatin And Etoposide With Or Without Tiragolumab In Patients With Untreated Extensive-Stage Small Cell Lung Cancer

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
3
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The purpose of this study is to evaluate the efficacy of tiragolumab plus atezolizumab and carboplatin and etoposide (CE) compared with placebo plus atezolizumab and CE in participants with chemotherapy-naive extensive-stage small cell lung cancer (ES-SCLC). Eligible participants will be randomized 1:1 to receive one of the following treatment regimens during induction phase:- -Arm A: Tiragolumab plus atezolizumab and CE -Arm B: Placebo plus atezolizumab and CE Following the induction phase, participants will continue maintenance therapy with either atezolizumab plus tiragolumab (Arm A) or atezolizumab plus placebo (Arm B).

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, AZ	Closed for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment
Rochester, MN	Closed for enrollment

Print study details

Site IRB:
20-001268
NCT ID:
NCT04256421
Sponsor Protocol Number:
GO41767

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

Mayo Clinic Location	Status	Contact
Rochester, MN	Contact us for the latest status	View complete study & contact information

A Study To Evaluate The Safety And Effectiveness Of The Augmented Endoscopy System For Mucosal Lesion Detection During Colonoscopy For Colon Rectal Cancer.

Scottsdale/Phoenix, AZ, Eau Claire, WI, Jacksonville, FL, La Crosse, WI

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A Study To Evaluate The Safety And Effectiveness Of The Augmented Endoscopy System For Mucosal Lesion Detection During Colonoscopy For Colon Rectal Cancer.

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to confirm the performance of the CB-17-08 software as a medical device (SaMD) to help endoscopist during the colonoscopy procedure to find potential mucosal lesions, including polyps, adenomas and carcinomas, without significant noise disturbing the endoscopist attention, nor negative interference with the lesions detection than with the standard endoscopy video alone. The study will evaluate whether high-definition white-light (HDWL) colonoscopy using CB-17-08 SaMD will have a lower miss rate of clinically significant polyps, as compared to standard HDWL colonoscopy alone (the current standard of care for colonoscopy).

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, AZ	Closed for enrollment	View complete study & contact information
Eau Claire, WI	Closed for enrollment
Jacksonville, FL	Closed for enrollment
La Crosse, WI	Closed for enrollment

Print study details

Site IRB:
19-007492
NCT ID:
NCT03954548
Sponsor Protocol Number:
CB-17-08/03

A Study To Evaluate The Safety And Effectiveness Of Tipifarnib In Head And Neck Cancer With HRAS Mutations And Impact Of HRAS On Response To Therapy

Rochester, MN
- See Details
A Study To Evaluate The Safety And Effectiveness Of Tipifarnib In Head And Neck Cancer With HRAS Mutations And Impact Of HRAS On Response To Therapy
- Study type:
  Interventional
  Describes the nature of a clinical study. Types include:
  
  Observational study — observes people and measures outcomes without affecting results.
  
  Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
  
  Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Study phase:
  2
  During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study

The purpose of this 2 cohort study is to evaluate the effectiveness of tipifarnib in HRAS mutant HNSCC (AIM-HN). The first cohort will assess the objective response rate (ORR) of tipifarnib in subjects with HNSCC with HRAS mutations. The second study cohort, SEQ-HN, is an observational sub-study and includes 2 types of patients: (1) the historical record of first line therapy in subjects with HRAS mutant HNSCC participating in Cohort 1 in whom first line outcome data are available and (2) matched control HNSCC patients in whom HRAS mutations were not identified (wild type HRAS HNSCC) and who consent to provide first line outcome data and additional follow up.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, MN

Closed for enrollment
View complete study & contact information

Print study details
Site IRB:
18-008378

NCT ID:
NCT03719690

Sponsor Protocol Number:
KO-TIP-007
A Study To Test Nivolumab With Usual Chemotherapy Treatment Or Usual Chemotherapy Treatment Alone To Treat Recurrent Or Metastatic Nasopharyngeal Cancer

Jacksonville, FL, Rochester, MN
- See Details
A Study To Test Nivolumab With Usual Chemotherapy Treatment Or Usual Chemotherapy Treatment Alone To Treat Recurrent Or Metastatic Nasopharyngeal Cancer
- Study type:
  Interventional
  Describes the nature of a clinical study. Types include:
  
  Observational study — observes people and measures outcomes without affecting results.
  
  Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
  
  Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Study phase:
  3
  During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study

The purpose of this study is to compare the effect of adding nivolumab to the usual chemotherapy (cisplatin or carboplatin with gemcitabine) versus the usual chemotherapy alone in treating patients with nasopharyngeal cancer that has come back (recurrent) or spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, carboplatin, and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving nivolumab with the usual chemotherapy may work better than the usual chemotherapy alone in treating patients with nasopharyngeal cancer.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Jacksonville, FL

Closed for enrollment
View complete study & contact information

Rochester, MN

Closed for enrollment

Print study details
Site IRB:
20-011655

NCT ID:
NCT04458909

Sponsor Protocol Number:
NRG-HN007

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

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Search Results 1861-1870 of 2905 for cancer

Evaluating Changes In Quality Of Life After Near Margin-less Adaptive Radiation Therapy Compared To Standard Stereotactic Ablative Body Radiotherapy In Localized Prostate Cancer

Assessment Of The Efficacy And Safety Of Olaparib Monotherapy Versus Physicians Choice Chemotherapy In The Treatment Of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.

Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer

A Study Of Atezolizumab Plus Carboplatin And Etoposide With Or Without Tiragolumab In Patients With Untreated Extensive-Stage Small Cell Lung Cancer

Efficacy And Safety Trial Of Apatinib Plus Best Supportive Care Compared To Placebo Plus Best Supportive Care In Patients With Gastric Cancer

A Study Of The Safety And Effectiveness Of Atezolizumab Combined With Etoposide, And Carboplatin For Patients With Untreated Extensive-Stage Small Cell Lung Cancer

A Two-Part Phase 3 Study Of Sofetabart Mipitecan (LY4170156) In Participants With Platinum-Resistant (Part A) And Platinum-Sensitive (Part B) Ovarian Cancer

A Study To Evaluate The Safety And Effectiveness Of The Augmented Endoscopy System For Mucosal Lesion Detection During Colonoscopy For Colon Rectal Cancer.

A Study To Evaluate The Safety And Effectiveness Of Tipifarnib In Head And Neck Cancer With HRAS Mutations And Impact Of HRAS On Response To Therapy

A Study To Test Nivolumab With Usual Chemotherapy Treatment Or Usual Chemotherapy Treatment Alone To Treat Recurrent Or Metastatic Nasopharyngeal Cancer

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