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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 45 for Infectious Diseases

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  • Study status: Open/Status Unknown
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  1. A Study Using VE303 to Prevent Recurrence of Clostridium Difficile Infection

    Rochester, MN

  2. Study Using Clofazimine to Treat Patients with Non-Tuberculous Mycobacterial Infections

    Scottsdale/Phoenix, AZ

  3. A Study to Evaluate Entolimod on Immune System Aging in Healthy Geriatric Subjects Receiving Influenza Vaccination

    Rochester, MN

  4. ECOSPOR IV: An Open-Label Extension of Study SERES 0012 Evaluating SER-109 in Subjects With Recurrent Clostridium Difficile Infection

    Rochester, MN

  5. A Study to Evaluate Biomarkers of Fluoroquinolone-induced Mitochondrial Toxicity

    Rochester, MN

  6. A Study to Evaluate the Effectiveness of Merimepodib in Adult Patients with Advanced COVID-1

    Scottsdale/Phoenix, AZ, Rochester, MN, Jacksonville, FL

  7. Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS)

    Jacksonville, FL

  8. A Study to Assess Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia

    Rochester, MN

  9. A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of ABBV-181 (Budigalimab) in Adult Participants With HIV-1

    Rochester, MN

  10. Molecular Analysis of Blood for the Detection of Cardiovascular Pathogens

    Rochester, MN

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