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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 46 for Laboratory Medicine and Pathology

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  • Study status: Open/Status Unknown
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  1. A Study to Understand Serum Biotin Clearance as a Means to Mitigate the Risk of Biotin Interference with Clinical Laboratory Tests

    Rochester, MN

  2. A Study to Evaluate Biomarkers of Fluoroquinolone-induced Mitochondrial Toxicity

    Rochester, MN

  3. Outcomes of Regional Consensus Treatment Guidelines for Management of Surgery, Invasive Procedures and Control of Hemorrhages in Patients with Bleeding Disorders; and Management of Thrombosis and Thromboprophylaxis in Patients with Thrombophilia

    Rochester, MN

  4. Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS)

    Jacksonville, FL

  5. Mesenchymal Stem Cells Therapy in Patients With Recent Intracerebral Hemorrhage

    Jacksonville, FL

  6. Leukapheresis using Amicus Separator

    Scottsdale/Phoenix, AZ, Rochester, MN

  7. A Study Comparing Recombinant Von Willebrand Factor (rVWF) vs. Tranexamic Acid (TA) to Minimize Menorrhagia in Women with Type 1 Von Willebrand Disease

    Rochester, MN

  8. A Study to Evaluate sPD-L1 Clearance in Patients Undergoing Plasma Exchange Therapy

    Rochester, MN

  9. A Registry to Collect Patient and Family DNA and Information for Anyone who has had Multiplex Testing and Gene Mutation Results

    Rochester, MN

  10. A Study to Determine Serum and Urine Reference Ranges in Patients with Normal Renal Function Being Administered Gadobutrol for an Enhanced Magnetic Resonance Imaging (MRI)

    Rochester, MN

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