Charles P. Hannon, M.D., M.B.A.

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• Corticosteroids in Total Knee Arthroplasty: How Many Dexamethasone Doses Should Be Given Perioperatively? A Randomized Controlled Trial (DEXA_PERIOP) Rochester, MN

  The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications

• Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty: A Prospective Randomized Controlled Trial Rochester, MN

  The purpose of this study is to evaluate the effectiveness and safety of tramadol and oxycodone therapy in comparison to oxycodone alone as part of a multimodal pain regimen to reduce postoperative opioid consumption, pain, minimize adverse events and complications for primary total knee arthroplasty (TKA) and primary total hip arthroplasty (THA).
  We hypothesize that for patients undergoing primary TKA or THA, the use of a combined tramadol and oxycodone therapy as part of a multimodal pain regimen will provide greater pain relief and less opioid consumption within 90 days after surgery without an increase in adverse events as compared to patients receiving oxycodone alone.

• Individualized Opioid Prescribing Following Total Joint Arthroplasty – Part 2 Rochester, MN

  The purpose of this this study is to create a Prospective Registry of Postoperative Opioid Consumption to Assess Model Validity and Complexity (Phase 2)