Faculty

Arman Arghami, M.D., M.P.H.

Clinical Studies

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Comparison of unipedal stance time with frailty scores in transcatheter aortic valve replacement patients Rochester, Minn.
The objective of this study is to compare the unipedal stance time with serum albumin, 5-meter walk test and KATZ questionnaire findings as frailty scores in transcatheter aortic valve replacement (TAVR) patients.
EnCompass Clamp And The AtriClip In Box Lesion And Left Atrial Appendage EXclusion Procedure For The Prevention Of New Onset Of Atrial Fibrillation Rochester, Minn. Post Operative Atrial Fibrillation (POAF) is the most common complication of cardiac surgery. POAF incidence can exceed 50% depending on the patient baseline characteristics and surgery type. Patients with POAF tend to have worse acute and long-term clinical outcomes. BoxX-NoAF is a randomized trial to evaluate if prophylactic ablation and exclusion of the Left Atrial Appendage at the time of other routine cardiac surgery can reduce the incidence of post operative AF and clinical AF during long term follow up in patients who have not yet developed AF but are at risk.
Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study Rochester, Minn.
The purpose of this study is to use a multimodal approach to mitral valve evaluation using cardiac CT and MRI, which have shown superior accuracy in assessing anatomic and functional parameters relative to standard-of-care echocardiography. By evaluating 30 patients undergoing robotic mitral annuloplasty, this study aims to establish the feasibility of further prospective evaluation of CT and MRI for preoperative risk stratification. Enhanced risk stratification could significantly improve patient outcomes.

Closed for Enrollment

A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study To Evaluate The Effect Of RBT-1 On Preconditioning Response Biomarkers In Subjects Undergoing Coronary Artery Bypass Graft (CABG) And/or Cardiac Valve Surgery (START) Rochester, Minn.
The purpose of this study is to evaluate the effect of RBT-1 on preconditioning response biomarkers in subjects who are at risk for acute kidney injury (AKI) following cardiac surgery.
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study To Evaluate The Effect Of RBT-1 On Reducing The Risk Of Post-Operative Complications In Subjects Undergoing Cardiac Surgery And Sub-Study Of Clinical Protocol REN-007: A Population Pharmacokinetic (PopPK) Evaluation Of RBT-1 Rochester, Minn.
The purpose of this study is is to evaluate the effect of RBT-1 on reducing the risk of post-operative complications in subjects undergoing cardiac surgery on cardiopulmonary bypass (CPB).
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study Of The Efficacy And Safety Of GDC-8264 In Preventing Cardiac Surgery-Associated Acute Kidney Injury And Major Adverse Kidney Events Rochester, Minn.
The purpose of this study is to evaluate the efficacy and safety of GDC-8264 compared with placebo in participants undergoing cardiac surgery who are determined to be at moderate to high risk of developing AKI and subsequent MAKE at 90 days after surgery (MAKE90).
A Prospective, Multi-center Trial To Evaluate The Safety And Effectiveness Of Beating Heart Mitral Valve Repair With The HARPOON™System (RESTORE), Protocol 2019-05 Rochester, Minn.
The purpose of this study is to evaluate the safety and effectiveness of the HARPOON System in the treatment of patients with severe degenerative mitral regurgitation.
Hybrid Convergent of Epicardial and Endocardial RF Ablation for the Treatment of Symptomatic Longstanding Persistent AF Rochester, Minn. The primary objective of CONVERGE PAS is to evaluate clinical outcomes (peri-procedural and long-term) in a cohort of patients treated during commercial use of the EPi-Sense® Guided Coagulation System or EPi-Sense ST™ Coagulation System to treat symptomatic long-standing persistent atrial fibrillation (AF) patients who are refractory or intolerant to at least one Class I and/or III AAD.

Arman Arghami, M.D., M.P.H.

Clinical Studies

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Arman Arghami, M.D., M.P.H.

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Clinical Studies

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