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  • A Clinical Pathway for the Treatment of Multifocal Lung Adenocarcinoma Using Genome Sequencing Rochester, Minn.

    To gather preliminary safety and outcome data for the multimodality treatment of lung adenocarcinoma in the setting of multifocal BAC.

  • A Phase I Study of iPS Cell Generation From Patients With COPD Rochester, Minn.

    As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells.

  • A Phase III Randomized Trial of Lobectomy Versus Sublobar Resection for Small (≤ 2 CM) Peripheral Non-Small Cell Lung Cancer Rochester, Minn.

    RATIONALE: Wedge resection or segmentectomy may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy are more effective than lobectomy in treating stage IA non-small cell lung cancer.

    PURPOSE: This randomized phase III trial is studying different types of surgery to compare how well they work in treating patients with stage IA non-small cell lung cancer.

  • A Pilot Study of Metformin as a Chemoprevention Agent in Non-small Cell Lung Cancer Rochester, Minn.

    The purpose of this study is to learn whether it is better to receive the drug Metformin with standard of care for lung cancer or just standard of care.

  • A Pilot Study to Isolate and Test Circulating Tumor Cells Using the ClearCell® FX EP+ System Rochester, Minn.

    The purpose of this study is to isolate and measure circulating tumor cells in the blood stream to advance detection of cancer and treatment monitoring. In this study, the investigators will utilize the novel technology for circulating tumor cell detection in order to evaluate their presence in patients with lung cancer.

  • Center for Regenerative Medicine Biotrust Biomaterial Repository Jacksonville, Fla.

    The purpose of this study is the growing and storage of stem cells, made using the tissue samples of patients and others. As new technologies develop, these cells may be able to be grown into new cells to replace those damaged by disease or injury.

  • Exceptional Responders Pilot Study: Molecular Profiling of Tumors From Cancer Patients Who Are Exceptional Responders Rochester, Minn., Scottsdale/Phoenix, Ariz.

    Background:

    - Cancer can happen when a person s genes change in a way that makes cells grow uncontrolled. Researchers want to see what changes in genes might make some people with cancer respond well to some treatments. This may lead to better ways to prevent, detect, and treat cancer and other diseases.

    Objectives:

    - To see what changes in genes might make some people with cancer respond well to some treatments.

    Eligibility:

    - People who are documented exceptional responders to cancer treatment. They must have given a tumor sample that is available to researchers.

    Design:

    • Participants will be screened with reports of their radiology scans or other evidence that shows exceptional response.
    • Participants will provide permission for researchers:
    • To test cancer tissue that has previously been removed.
    • To test normal tissue (blood) that has previously been collected, if available.
    • To obtain data from their medical records.
    • Data will be kept in an anonymous database. Other researchers may share the data.
    • No new tissue will be collected from participants.
  • Identification of Prognostic Biomarkers for Progression of Invasive Squamous Cell Carcinoma Rochester, Minn.

    The study will utilize both retrospective and prospective data collection from patients that already had a bronchoscopy and lung resection or will have a bronchoscopy and lung resection for squamous cell carcinoma. The investigators plan to prospectively collect 5 bronchoscopic biopsies, 3ml blood and one tumor and adjacent normal samples from 200 qualified patients who meet the study criteria.

  • Isolation, Activation and Expansion of Mutation Reactive T-cells Rochester, Minn.

    The purpose of this study is to examine the ease and practicality of extracting central memory T-cells and the potential for their activation and ability to recognize tumor antigens and target lung cancer cells for destruction.  Circulating cell-free DNA (cfDNA) from the plasma will be extracted and sequenced to identify somatic mutations that were exposed to the T-cells.

  • Measuring Cell Free DNA During the Course of Treatment for Esophageal Cancer as a Marker of Response and Recurrence Rochester, Minn.

    To prospectively collect blood and tumor tissue from esophageal cancer patients to identify specific esophageal cancer mutations that can be measured in the blood (cell free DNA) during the course of treatment as a marker of response and recurrence.

    To prospectively collect blood and tumor tissue from esophageal cancer patients to identify specific esophageal cancer mutations that can be measured in the blood (cell free DNA) during the course of treatment as a marker of response and recurrence.

  • Progenitor Cells in Human Esophagus Rochester, Minn.

    The purpose of this study is to better understand how esophageal cells change with age.

  • Randomized Phase II Trial of Stereotactic Body Radiotherapy (SBRT) versus Sublobar Resection for High-Risk Patients with Early Stage Non-Small Cell Lung Cancer (NSCLC) ≤ 5cm Rochester, Minn.

    This randomized phase II trial is for medically inoperable early stage non-small cell lung cancer (NSCLC) patients. It is designed to compare the number of patients who are disease free and alive at 2 years between Stereotactic Body Radiotherapy (SBRT) and surgical intervention arms. SBRT is less invasive and felt to be equally effective to surgery for early stage NSCLC. Surgery is currently the standard of care for these patients. The hypothesis of this study is that SBRT is at least as good as surgery for disease free survival at 2 years.

  • Use of Intra-Operative Shear Wave Ultrasound Vibrometry for Characterization of Esophageal Malignant Tumors Rochester, Minn.

    Using the analysis of group velocity for a screening application and then higher order analysis based on the elastic and viscious components of the shear modulus may allow discrimination between extent of tumor invasion through the esophageal wall if appropriately correlated with pathological findings.

  • Yield and Quality of Genetic Analytes (DNA and RNA) Extracted from Esophageal Tissues after Esophagectomy Rochester, Minn.

    The purpose of this study is to learn about why esophageal cancer develops. We would like to test the tissue to find out which way of saving esophageal tissue gives us the best information (DNA and RNA) to use for future studies and collect a blood sample to use as a comparison for normal and tumor DNA.

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