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  • Inherited Breast Cancer Study Rochester, Minn.

    The purpose of this study is to improve the interpretation of mutations in breast cancer predisposition genes. This will be accomplished by recruiting members of families found to carry deleterious (mainly protein truncating) mutations and evaluating co-segregation of the mutations with cancer within families.

  • Prospective Registry of Multiplex Testing (PROMPT) Phase II (PROMPT) Rochester, Minn.

    The purpose of this study is to collect patient and family DNA and disease data to learn more about how changes in certain genes may be linked to cancer. Some people with cancer may have aquired their disease because they inherited an abnormal (mutated) gene. The researchers of this study want to better understand the risks that are linked to genetic changes in these less well-studied genes. By understanding these risks, it is believed that doctors will be able to give better advice to families with mutations in these genes.

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  • Inherited Breast Cancer Study Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

    The purpose of this study is to improve the interpretation of mutations in breast cancer predisposition genes. This will be accomplished by recruiting members of families found to carry deleterious (mainly protein truncating) mutations and evaluating co-segregation of the mutations with cancer within families.

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  • Collection of Specimens and Clinical Data for Patients with Recurrent or Metastatic Breast Cancer or Male Breast Cancer Rochester, Minn.

    The purpose of this study is to collect blood samples and fresh tissue from biopsies of metastatic lesions from Mayo Clinic patients with metastatic breast cancer. The biospecimens will be used for analysis of genetic alterations in germline and tumor DNA and for tracking of response to therapy using blood-based liquid biopsy approaches. 

  • The Predicting Risk after Screening Mammogram (PRISM) Study (PRISM) Rochester, Minn.

    The purpose of this study is the creation of a long-term prospective observational study of women undergoing screening mammography at Mayo Clinic. The cohort will be used to evaluate risk models for breast cancer incorporating epidemiological risk factors, genetic risk factors, breast density measures, imaging data, results from diagnostic tissue biopsies, and liquid biopsy assays. The cohort will also be useful for clinical validation and assessment of clinical utility of predictive and prognostic biomarkers for breast cancer.

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