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A Phase 0/Ia Study Of BI 907828 Concentrations In Brain Tissue And A Non-randomized Open-label, Dose- Escalation Study Of BI 907828 In Combination With Radiotherapy In Patients With Newly-diagnosed
Glioblastoma
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.,
Jacksonville, Fla.
The purpose of this study is to examine the pharmacological effects of the compound BI 907828 on patient tumors at an early stage of drug development.
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A Phase II Randomized Trial Of Proton Vs. Photon Therapy (IMRT) For Cognitive Preservation In Patients With IDH Mutant, Low To Intermediate Grade Gliomas
Rochester, Minn.
This randomized phase II clinical trial studies the side effects and how well proton beam or intensity-modulated radiation therapy works in preserving brain function in patients with IDH mutant grade II or III glioma. Proton beam radiation therapy uses tiny charged particles to deliver radiation directly to the tumor and may cause less damage to normal tissue. Intensity-modulated or photon beam radiation therapy uses high-energy x-ray beams shaped to treat the tumor and may also cause less damage to normal tissue. Patients will be more likely to be randomized to proton beam radiation therapy. It is not yet known if proton beam radiation therapy is more effective than photon-based beam intensity-modulated radiation therapy in treating patients with glioma.
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Genomic Analysis of Glioma Tissue Samples
Rochester, Minn.
The purpose of this study is to use stored glioma specimens stored by the Tissue Registry under the oversight of the Neuro-Oncology program.
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Image-based Mapping Of Brain Tumors
Rochester, Minn.
The purpose of this study is to combine MRI images with histologic and genetic analysis of cancer (from blood and tissue samples) to improve the overall accuracy of diagnosis and effectiveness of cancer treatment.
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Pilot Study To Assess Heterogeneity Of The Blood Brain Barrier In Patients With CNS Malignancy
Rochester, Minn.
This pilot research trial studies blood brain barrier differences in patients with brain tumors undergoing surgery. Studying samples of tissue and blood from patients with brain tumors in the laboratory may help doctors to understand how well drugs get into different parts of a brain tumor. This may help them to determine which types of drugs may be best for treating brain tumors.
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