Andrea Mariani, M.D., M.S.

Closed for Enrollment

• 3D in vitro Model Systems for Serous Endometrial Cancer Rochester, Minn.

  The purpose of this research study is to learn more about serous endometrial cancer by creating three-dimensional (3-D) tissue models in the laboratory setting.  The tissue models will provide scientists with a reliable, sensitive method to test biomarkers and cellular responses to treatment for endometrial cancer.   

   

• Accuracy of Three-Dimensional Ultrasound in the Determination of Tumor Volume and Myometrial Invasion in Endometrial Cancer: A Pilot Study Rochester, Minn.

  The purpose of this study is to evaluate sensitivity and specificity of 3D ultrasound in the assessment of tumor diameter and myometrial invasion in endometrial cancer in a pre-operative setting. This research is aiming to avoid the performance of sentinel node biopsy in patients at low risk of lymphatic spread.

• Efficacy of PET/MRI in Detecting Metastatic Disease in Endometrial Cancer Rochester, Minn.

  The purpose of this study is to evaluate the ability of PET/MRI (Positron Emission Tomography/Magnetic Resonance Imaging) to give physicians preoperative information about specific sites in the body that the endometrial cancer may be present. If the PET/MRI is accurate and successful in providing this information, then women in the future may be able to have less extensive surgery for their endometrial cancer after evaluation with PET/MRI.

• Ovarian Cancer Microbiome Signatures Rochester, Minn.

  The purpose of this study is to characterize the microbiome in the genital tract and in the peritoneal cavity of subjects with ovarian, fallopian tube, and primary peritoneal cancer.

• Surgical Sample Collection- Vaginal and cervical sampling during uterine surgery Rochester, Minn.

  The purpose of this study is to learn the optimal vaginal sample collection process, including preferred anatomical location and yields and quality of RNA and DNA from each anatomical location.