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Analysis of Circulating Tumor DNA in Breast Cancer: Can We Predict Pathological Complete Response following Neoadjuvant Treatment?
Scottsdale/Phoenix, Ariz.
This project will investigate whether ctDNA analysis in newly diagnosed stage I, II, III breast cancer patients treated with neoadjuvant systemic therapy can predict pathological Complete Response (pCR).
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GENetic Risk Estimation of Breast Cancer Prior to Decisions on Preventive Therapy Uptake, Risk Reducing Surgery or Intensive Imaging Surveillance: A Study to Determine if a Polygenic Risk Score Influences the Decision Making Options Amongst High Risk Women (GENRE 2) (GENRE2)
Jacksonville, Fla.,
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.
The primary aim of this study is to determine if the addition of an individual polygenic risk score (PRS) in addition to the Breast Cancer Risk Assessment Tool (BCRAT) or Tyrer-Cuzick (IBIS) score will aid women at risk of breast cancer in making a decision to take (or not take) medications to prevent breast cancer.
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Living Breast Organoid Biobank for Translational Research
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.,
Jacksonville, Fla.
Researchers at Mayo Clinic are developing a Biobank of adult stem cell-rich breast organoids, a new research resource to facilitate normal and cancer stem cell research. Subjects in the Biobank will provide samples of excess breast tissue, complete a health questionnaire, and allow access to medical records now and in the future. The Biobank serves as a library for researchers; instead of having to look for volunteers for each new project, researchers can use samples from the Biobank as well as share information already collected.
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Pre-analytical Factors Affecting ctDNA Analysis in Early and Locally-advanced Breast Cancer
Scottsdale/Phoenix, Ariz.
The purpose of this study is to evaluate the impact of blood collection tube type and processing methods on ctDNA, evaluate the impact of long-term storage of plasma and extracted DNA, and evaluate ctDNA levels at baseline and during treatment for patients with Stage I-III breast cancer.
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Sentinel Lymph Node Working Group
Scottsdale/Phoenix, Ariz.
The purpose of this study is to establish and analyze a large database on the outcomes of patients undergoing selective SLND, we hope to correlate a pattern of recurrence with selected patient characteristics. These results have the potential of giving physicians the ability to predict outcomes for future cancer patients and provide them a more effective course of treatment.
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