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  • A Resource of Blood and Other Biospecimens of Patients With Cholestatic Liver Disease and Unaffected Individuals Rochester, Minn.

    This study is a biobank of specimens and clinical data for use in current and future research to better understand the cholestatic liver diseases primary biliary cirrhosis/cholangitis (PBC) and primary sclerosing cholangitis (PSC).

  • Characterization of Biliary Cell-derived Organoids from Bile of PSC and Non-PSC Patients Rochester, Minn.

    The objectives of this study are to establish and perpetuate human biliary cell-derived organoids, to assess genetic and signaling pathway alterations in organoids derived from PSC patients as compared to Non-PSC patients, and to investigate the potential utility of organoids in the in vitro testing of experimental drugs.

  • Mayo Clinic Health TAPESTRY: Use of Genomic Sequencing in Clinical Practice (TAPESTRY) Rochester, Minn., Scottsdale/Phoenix, Ariz., Jacksonville, Fla.

    Tapestry is a Mayo Clinic research study, which includes receiving genetic sequencing data from Helix, up to the full whole exome dataset. The goal of this study is to provide: (i) an immediate interpretation of ancestry/genealogy and several non-disease traits, as well as, clinically actionable variants for an inherited form of high cholesterol called familial hypercholesterolemia (FH), breast and ovarian cancer (HBOC), and Lynch syndrome to each participant; (ii) an additional subset of focused clinically actionable genetic findings, such as, certain types of hereditary cancers, hereditary heart conditions and severe responses to certain medications, will be returned to the provider and to the participant, via the provider, genetic counselor consultation, and/or Mayo Clinic research interpretation; (iii) storing of genomic and phenotypic data for future research analysis.

  • Mayo Clinic IBD Biobank Rochester, Minn.

    The purpose of this study is to better understand disease development of Irritiable Bowel Disease (IBD) and related diseases as a step to improving disease outcomes.

  • Patient Experience and Satisfaction with Predictive Genomic Testing Ordered Through SL3 Rochester, Minn.

    The purpose of this study is to better understand the impact of predictive genomic testing in the healthy adult population by assessing decisional satisfaction/regret, understanding of disease risk, lifestyle modifications, and satisfaction with the testing experience. 

     

  • Whole Exome Sequencing for Diagnostic Odyssey Cases Evaluated at the Individualized Medicine Clinic Scottsdale/Phoenix, Ariz., Rochester, Minn.

    The purpose of this study is to test a new set of technologies called Next Generation Sequencing (NGS) that may help identify possible genetic reasons for your medical condition. NGS is a procedure that looks at all of your genes (the genetic material you have inherited from your parents) in different ways. Right now, clinical NGS is only done in outside clinical labs. In this study, Mayo Clinic is developing procedures to perform and interpret NGS in its own clinical labs. We also want to store samples and genetic information for future research.

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