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  • Home Visual Acuity Testing (X06) Rochester, Minn.

    Management of most pediatric eye conditions requires periodic monitoring of visual acuity (VA).
    In many cases, particularly the treatment of amblyopia, measurement of VA is the key clinical
    outcome of the clinical examination done in the office. However, transporting children and
    teenagers to and from the care provider’s office to obtain follow-up measurements of VA can be
    difficult due to the need to take time off work and school. In addition, transportation can be a
    barrier because of access or cost or both. Additionally, the recent emergence of the COVID-19
    pandemic and subsequent global “shelter in place” and “lockdown” precautions have further
    highlighted the need for a validated method of measuring VA at home, to enable the monitoring
    of eye conditions in the context of telemedicine.
    The present study is designed to evaluate whether VA measured at home by a parent or guardian
    using the age appropriate ATS-HOTV or e-ETDRS testing protocol on an iPhone-based
    application (hereafter referred to as “phone-based” method) will result in measurements similar to
    those collected during an office visit at an eye clinic using the same testing protocol on a study
    certified EVA or M&S visual acuity tester (hereafter referred to as “office-based” method).

Closed for Enrollment

  • A Prospective Observational Study of Adult Strabismus (SAS1) Rochester, Minn.

    The purpose of this study is to describe clinical characteristics, treatments, and one-year outcomes for adults who have convergence insufficiency, divergence insufficiency, or small angle hypertropia.

  • A Randomized Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia (IXT5) Rochester, Minn.

    The main objectives of this randomized trial comparing overminus lens treatment to non-overminus (spectacles without overminus or spectacles with plano lenses) are to determine: - The long-term on-treatment effect of overminus treatment on distance IXT control score. - The off-treatment effect of overminus treatment on distance IXT control score (following weaning and 3 months off treatment).

  • A Randomized Trial of Bilateral Lateral Rectus Recession Versus Unilateral Lateral Rectus Recession With Medial Rectus Resection for Intermittent Exotropia (IXT1) Rochester, Minn.

    The purpose of this study is to evaluate the effectiveness of bilateral lateral rectus muscle recession versus unilateral lateral rectus recession with medial rectus resection procedures for the treatment of basic type and pseudo divergence excess type intermittent exotropia.

  • Augmenting Patching Treatment for Amblyopia with Physical Exercise Rochester, Minn.

    The purpose of this study is to establish whether moderate physical exercise enhances treatment benefit when patching 2 hours a day for residual amblyopia in children.

  • Binocular Dig Rush Game Treatment for Amblyopia (ATS20) Rochester, Minn.

    The purpose of the study is to compare the efficacy of 1 hour/day of binocular game play 5 days per week plus spectacle correction with spectacle correction only, for treatment of amblyopia in children 4 to <13 years of age.

  • GLASSES VERSUS OBSERVATION FOR MODERATE HYPEROPIA IN YOUNG CHILDREN (HTS1) Rochester, Minn. Some doctors feel that a child with hyperopia (farsightedness) should have glasses before any potential vision problems (such as amblyopia or strabismus) develop. Other doctors feel that children should not be given glasses unless vision problems occur. It is not known if hyperopia should be treated immediately or only if other problems occur. This is the reason this randomized clinical trial is being done.
  • Intermittent Exotropia Study 6: A Pilot Randomized Clinical Trial of Base-in Prism Spectacles for Intermittent Exotropia (IXT6) Rochester, Minn.

    The purpose of this study is to compare spectacles with relieving prism to spectacles without prism to determine whether to proceed to a full-scale, longer-term randomized trial. This decision will be based primarily on assessing the initial (8-week) response to prism by comparing treatment groups on the following outcomes: 

    • Mean distance intermittent exotropia (IXT) control score (the mean of 3 control scores) (primary outcome);
    • The proportion of participants demonstrating a "treatment response," defined as ≥ 1 point improvement in the mean distance IXT control score without spontaneous exotropia during control testing (secondary outcome);
    • The proportion of participants reporting adverse effects and good/excellent spectacle wear compliance.
  • Pediatric Cataract Surgery Outcomes Registry Rochester, Minn. This study is being done to learn about cataract surgery in children. The study involves the collection of information about children who have had cataract surgery. This information will include when the child developed cataract, how the cataract has been treated, problems that may have occurred related to surgery, and whether anyone else in the family has had a cataract. Doctors throughout the United States and possibly other parts of the world are taking part in the study. We hope that gathering the information from many children we can improve the care of children with cataracts.
  • Pediatric Optic Neuritis Prospective Outcomes Study (PON1) (PON1) Rochester, Minn.

    The primary outcome is visual acuity at 6 months. Secondary aims will be to characterize optic neuritis in a large  multicenter cohort of children and to assess the risk of development of MS at two years.

     

     

  • Signs and Symptoms of Retinal Disease Rochester, Minn.

    The aim of this study is to determine which clinical characteristics are associated with diplopia in patients with epiretinal membranes. 

  • Treating Amblyopia in Adults with Interactive Video Games Rochester, Minn.

    The purpose of this study is to establish whether or not interactive video game play provides a means of treating amblyopia in adults.

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