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Closed for Enrollment
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial of Oral IW-3718 Administered to Patients With Gastroesophageal Reflux Disease While Receiving Proton Pump Inhibitors
La Crosse, Wis.,
The purpose of this study is to evaluate the safety and effectiveness of IW-3718 administered to patients with GERD who continue to have persistent symptoms, such as heartburn and regurgitation, while receiving once-daily (QD), standard-dose proton pump inhibitors (PPIs).
Esophageal Disease in Patients with Lung Disease: From Chronic Cough to Lung Transplantation
The purpose of this study is to characterize esophageal function across a broad spectrum of pulmonary disease.
- By exploring whether mortality and allograft rejection (acute and chronic) differs in patients with gastroesophageal reflux (GER) from those without GER, following lung transplantation.
- By identifying specific patterns in the type/severity of GER (acid/non-acid, proximal/distal) and esophageal dysmotility (impaired reflux clearance, impaired bolus transit, decrease post-reflux swallow induced peristalsis) that will associate with respiratory function and symptoms; and in the transplant patients, post-transplant outcomes and chronic lung allograft dysfunction.
Gastrointestinal Lewy Bodies: A Cause or Effect of Parkinson’s Disease? Investigation of Etiologies Causing Gastrointestinal Disorders and Potential Links to CNS Disease.
The purpose of this proposal is to explore whether the presence of Lewy pathology in the gastrointestinal tract is associated with functional disturbances such as constipation and dysphagia in both Parkinson’s disease patients and non-Parkinson’s disease patients, and if present in the latter patients whether this relates to the subsequent development of Parkinson’s disease.
Pilot Studies Evaluating Cough Reflex Sensitivity and Bronchial Hyper-responsiveness: The Road to Cough and Wheeze in Patients with Gastroesophageal Reflux
The aim of this study is to provide pilot data on the possible gastrointestinal predictors of respiratory hyper-responsiveness and how these relate to the clinical sub-types of GERD and visceral acid hypersensitivity.