Gregory D. Cascino, M.D.

The purpose of this study is to validate the results of previous studies at the University of Pennsylvania and the Mayo Clinic, indicating that the EvoScoreDX algorithm can differentiate patients suffering from psychogenic nonepileptic seizures (PNES) and epileptic seizures (ES) using identified proteins, demographic, and clinical data.

The purpose of this study is to evaluate the safety of giving repeat doses of NRL-1 when it is used to treat people who have epilepsy.

The purpose of the study is to evaluate the effectiveness, safety and tolerability of the 3 selected dose regimens of padsevonil (PSL) administered simultaneously with up to 3 anti-epileptic drugs (AEDs) compared with placebo for treatment of observable focal-onset seizures in adult subjects with drug-resistant epilepsy.

The purpose of this study is to confirm the results of a University of Pennsylvania pilot study indicating that the EvoScoreDX algorithm can differentiate patients suffering from psychogenic nonepileptic seizures (PNES) and epileptic seizures (ES) using identified proteins, demographics, and clinical data.

The purpose of this study is to identify genetic causes for epilepsy (sometimes referred to as seizure disorders) and associated co-morbidities such as developmental delay (DD), intellectual disability (ID), and other neurological or neurodevelopmental disorders. We are collecting genetic and clinical information from individuals who have undergone exome/genome sequencing as part of their regular medical care or as part of a research study.

The purpose of this study is to identify clinical characteristics and biomarkers predictive of disease outcome, progression, and treatment response in participants with treatment-resistant focal epilepsy.

The purpose of this study is to identify clinical characteristics and biomarkers predictive of disease outcome, progression, and treatment response in participants with idiopathic generalized epilepsy (IGE).

The purpose of this study is to find out if home-recorded Smartphone videos can be used to accurately diagnose epilepsy in patients seeking evaluation for seizures. The idea is to compare the home-recorded video to video-EEG monitoring, which is the current gold-standard for diagnosis.

HEP is a five-year, prospective, observational study whose primary goal is to identify clinical characteristics and biomarkers predictive of disease outcome, progression, and treatment response in participants with newly treated focal epilepsy.