-
A Study of the Effectiveness and Safety of Subcutaneous Semaglutide for Patients with Fatty-Liver Disease, not Caused by Alcoholism
Rochester, MN
The purpose of this study is to investigate the effectiveness and safety of three dose levels of subcutaneous semaglutide for the treatment of patients who have fatty-liver disease not caused by alcoholism.
-
Study To Evaluate Efficacy, Safety And Tolerability Of HM15211(Efocipegtrutide) In Subjects
Rochester, MN
This study is a phase 2 study to Evaluate Efficacy, Safety and Tolerability of HM15211 Treatment for 12 Months in Subjects with Biopsy Confirmed NASH
-
Cohort of Patients With Fatty Liver Disease
Jacksonville, FL
The purpose of this research is to create a registry of patients having or at risk for metabolic liver disease for investigations into the molecular pathogenesis of cirrhosis, liver cancer, and end-stage liver disease.
-
A Study Evaluating the Effectiveness of Ultrasound Imaging for Liver Steatosis Staging
Rochester, MN
The purpose of this study is to investigate the effectiveness of ultrasound imaging for staging liver steatosis, using liver fat content measured by MRI as the reference standard.
-
A Study Evaluating Efruxifermin In Subjects With Compensated Cirrhosis Due To NASH/MASH
Rochester, MN
This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with compensated cirrhosis due to NASH/MASH.
-
Transforming Non-Invasive Liver Disease Detection by Magnetic Resonance Elastography
Rochester, MN
A variety of liver insults lead to pathological changes in liver architecture that culminate in cirrhosis. While invasive liver biopsy was required to detect cirrhosis, the development of magnetic resonance elastography (MRE) has revolutionized our ability to detect liver fibrosis through non-invasive means that involve measurement of liver stiffness. However, a number of pathological findings occur in liver in response to various insults that precede cirrhosis and are clinically important to identify such as steatosis associated with NASH, inflammation associated with viral hepatitis, and congestion associated with cardiac hepatopathy. Detection of such entities provides essential diagnostic, prognostic, and treatment information ...
-
Post-transplant NASH Protocol to Assess the Development of Metabolic Co-morbidities and Disease Recurrence in Patients Transplanted for NASH Cirrhosis
Rochester, MN
The purpose of this study is to identify risk factors and potential predictors for NAFLD and NASH recurrence after liver transplantation.
-
A Study To Develop A Resource (Bank) Of Biospecimens And Data Collected From Individuals With Liver Disease And Without Liver Disease
Rochester, MN
The purpose of this study is to facilitate discovery and development of novel biomarkers of risk and early detection, etiologic factors relating to liver disease, and novel targeted therapeutic and chemopreventive strategies for liver disease such as PSC, PBC, PLD, NAFLD, NASH, ASH, HCC, donors (non-diseased and diseased) for liver transplant or non-liver diseased subjects scheduled for surgery will serve as controls.