Clinical Trials

The researchers are trying to answer if axillary reverse mapping (ARM) with lympho-venous bypass (LVB) in patients undergoing an axillary lymph node dissection reduces the rate and severity of post-operative lymphedema of the arm.

The purpose of this study is to estimate the difference in viscoelasticity parameters between the affected and unaffected arms and legs among patients diagnosed with lymphedema.

The purpose of this study is to investigate outcomes for all patients with upper or lower extremity lymphedema with lymph node transfer in a two stage procedure involving dermal regeneration followed by split thickness skin graft (STSG) and compared to patients only receiving STSG for wound coverage.

The purpose of this study is to determine if ultrasound surface wave elastography (USWE) produces different recording patterns in healthy and lymphadematous limbs, to establish the relationship between USWE recording values and stages of lymphedema, and to understand the correlation between USWE lymphedema evaluation and other tracking modalities.

The purpose of this study is to validate the use of a lymphatic imaging protocol to stage disease severity in patients with lymphedema and serve as a biomarker for microsurgical treatment response.

The purpose of this study will be collection of standard and routinely obtained data specifically in the preoperative evaluation; operative room, postoperative/hospitalization period, and long term follow from the electronic medical record. 

The purpose of this study is to better understand the anatomy of the lymphatic structure and the molecular process that leads to the over production of lymph fluid.  This proposal will begin intense lymphedema screening and identify baseline characteristics potentially predisposing someone to lymphedema, and identify molecular markers that might be altered to prevent lymphedema. 

The correlation between lymphedema and shoulder arthroplasty will be analyzed using medical records for all patients that came to the Mayo Clinic with a diagnosis of lymphedema within the time period of 1979-2016.

We will use multiple variables to analyze the associations between lymphedema and multiple other factors, including infection, recurrence of disease, implant failure, etc.

The purpose of this study is to address current gaps in research by further establishing a possible correlation between chest wall and breast lymphedema, as measured by the Delfin Moisture Meter D Compact, to a decreased quality of life (LymQOL-midline questionnaire) as well as decreased shoulder function (DASH questionnaire). 

Lymphaticovenous anstomosis is an effective surgery to treat lymphedema in the upper extremities secondary to cancer treatment. A crucial step is to identify patent lymphatic channels. Contrast enhanced ultrasound (CEUS) with intradermal injection of microbubbles is a promising method for lymphatic mapping in the upper extrmeities with lymphedema. The goals of the study are(1) to establish the preferred FDA approved microbubble agent (Lumason, Optison, Definity) for CEUS lymphatic mapping, (2) to identify lymphatic channels with CEUS and high-frequency ultrasound in patients receiving lymphaticovenous anastomosis surgery for upper extremity lymphedema, (3) and to validate the use of shear wave elastography for detecting improving in ...

This study aims to assess the utility of pharyngeal manometry measures as a novel approach in quantifying  internal lymphedema and compare success rates in reducing internal lymphedema using manual lymphatic drainage (MLD) versus use of a pneumatic compression device (PCD). It also aims to assess efficacy of PCD and MLD and assess compliance of treatment in both groups. Lastly, it aims to identify voice and swallowing changes in both groups.