Clinical Trials

The purpose of this study is to collect and analyze neuroimaging, genetic markers, and clinical presentations and progressions of chronic traumatic encephalopathy to develop methods of diagnosing the disease during life. 

Hepatic encephalopathy (HE) is a serious complication of cirrhotic stage liver disease. It is reported that 30-70% of all patients with cirrhosis have HE. The current diagnostic methodology for HE includes a blood lab monitoring of ammonia and neuropsychometric testing, which can define the diagnosis but cannot assess the vitally important daily variability of this complication.

There are, however, distinct cognitive neurologic findings in HE that could be mapped and exploited for quick and accurate daily assessment. Vocal changes and speech analysis may provide guidance in the diagnosis and management of HE. The computer algorithm calculating vocal changes in HE would be ...

The purpose of this study is to determine if a mobile application used to label stools according to the Bristol Stool Scale can safely assist subjects with lactulose titration and lead to decreased rates of hepatic encephalopathy. Additionally, to assess patient willingness to interact with mobile application in taking pictures of bowel movements.

The purpose of this study is to assess the effectiveness and safety of rifaximin SSD-40IR for the delay of the first episode of overt hepatic encephalopathy (OHE) decompensation in liver cirrhosis, defined by the presence of medically controlled ascites. Participants who have cirrhosis determined by histopathological evidence, transient elastography or presence of esophageal varices, and who have not previously experienced OHE, spontaneous bacterial peritonitis (SBP), esophageal variceal bleeding (EVB), or acute kidney injury-hepatorenal syndrome (AKI-HRS) will be enrolled in the study. 

The purpose of this study is to determine whether ornithine phenylacetate can speed recovery from an acute hepatic encephalopathy episode requiring hospitalization in cirrhotic patients.

early detection of hepatic encephalopathy

The purpose of this study is to evaluate the psychometric properties of the newly developed Neurobehavioral Dysregulation Questionnaire (NBD‑Q) in the DIAGNOSE CTE‑II cohort at Mayo Clinic Arizona to inform its inclusion as a study measure for neurobehavioral dysregulation in TES/CTE research.

The purpose of this study is to assess how accurately a portable single-channel EEG device (Epilog™ by Epitel) detects generalized non-convulsive seizures, and to determine the feasibility of use of this device in an acute setting such as the Emergency Department (ED).

This is a single patient IND using Ampyra. The purpose of using Ampyra in this patient with epileptic encephalopathy is to control her epileptic seizures and prolong seizure free intervals.

This (DEEp OLE Study) is a multicentre, open-label study to investigate the long-term safety, efficacy, tolerability, and pharmacokinetics (PK) of LP352 in the treatment of seizures in children and adults with DEE who completed Study LP352-301 or LP352-302. The study consists of 3 main phases: Screening, Titration period and Maintenance period, followed by a Taper period and Follow-Up. The total duration of the study will be approximately 14 months.

The purpose of the study is to evaluate the safety of Rifaximin or placebo in subjects with severe hepatic impairment and Hepatic Encephalopathy.

The purpose of this study is to enable the recognition ability of a camera by providing its training in advance to detect breathing tubes and oxygen masks on any person’s face and reliably recognize signature features of acute brain failure displayed by the patient.

The specific aim for this study is to develop a Computer Vision model using a camera to automatically detect the presence of an endotracheal tube (ETT), an oxygen mask, or a noninvasive ventilation device on patients in the ICU.Digital Video Recordings (DVRs) have played an important role in patient care as preventive and remote monitoring. ...

The purose of this study is to assess the effectiveness and safety of rifaximin SSD-40mg IR for the delay of the first episode of overt hepatic encephalopathy (OHE) decompensation in liver cirrhosis, defined by the presence of medically controlled ascites.

The North American Mitochondrial Disease Consortium (NAMDC)maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.

The purpose of this study aims to retain and grow DIAGNOSE-I and examine the clinical and biomarker course of TES; investigate risk and resilience factors of TES; and compare biomarkers of amyloid (Aβ), p-tau, neurodegeneration, neuroinflammation, and white matter (WM) injury between TES and AD.

The purpose of this study is to identify the clinical characteristics, the management and the outcomes of acute kidney injury (AKI) in patients with cirrhosis worldwide. Additionally, to establish the severity of AKI across different regions, to identify precipitants of AKI across different centers, to identify the phenotypes of AKI across different centers, to evaluate differences in the management of AKI across different centers and their impact on clinical outcomes, and to assess outcomes of acute kidney injury (resolution of AKI, in-hospital mortality, 28-day mortality, 90-day mortality).

The purpose of the study is:

1. To determine the incidence of subclinical electrographic seizures and electrographic status epilepticus in children admitted to the PICU for head trauma, traumatic brain injury (TBI), and/or child abuse at National Children’s Hospital in Hanoi, Vietnam.

2. To determine whether a correlation exists between length of stay, morbidity, and mortality with incidence of subclinical SE and seizures.

The purpose of this study is to establish a repository consisting of clinical information, radiological data, serum, peripheral blood lymphocytes, plasma, cerebrospinal fluid (CSF), urine, stool, DNA and tissue specimens collected from patients who have central nervous system (CNS)  inflammatory diseases.