Clinical Trials

The purpose of this study is to provide all studies that contribute to the Mayo Clinic Adult Congenital Heart Disease (MACHD) Registry with a control cohort, this study will combine all testing needed for each of the studies. 

The purpose of this study is to create a standardized cardiac MRI imaging protocol for patients with Congenital Heart Disease. 

The purpose of this study is to explore the potential role of NOAC as an alternative therapy in the congenital heart disease population.

The primary purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between echocardiographic assessments performed at rest versus exercise. 

The purpose of this study is to characterize the relationship between NT-proBNP levels obtained at time of admission for delivery and subsequent cardiovascular events in ACHD patients, and to describe normative values for NT-proBNP at time of admission for delivery in an uncomplicated obstetric population.

The purpose of this study is to determine if vasodilators for the lungs can decrease liver stiffness, shown by Magnetic resonance elastography (MRE).  The study also aims to identify any clinical, laboratory, echocardiographic, imaging, and hemodynamic parameters that connect with improved outcomes of cardiac and liver status after starting the pulmonary vasodilators.

The purpose of this study to test the feasibility and safety for autologous (from your own body) skin cells that are manufactured into stem cells of cardiac lineage to be delivered into the heart muscle to determine if those stem cells will strengthen the heart muscle and can be used as an additional treatment for the management of  congenital heart disease. 

The eventual goal of this study is to identify genetic and proteomic markers that may influence susceptibility to vascular diseases including peripheral arterial disease, pulmonary hypertension, carotid artery stenosis, arterial aneurysmal disease, fibromuscular dysplasia, congenital heart disease and other less common diseases that affect the blood vessels.

The purpose of this study is to determine the optimal medical therapy to improve left ventricular (LV) function. Improvement in LV function has the potential to reduce the burden of heart failure and improve clinical outcomes in the Tetralogy of Fallot (TOF) population.

The purpose of this study is to compare the difference in the ability to detect blood flow abnormalities between invasive assessments performed at rest versus exercise.

The purporse of this study is to determine if biomarker assay obtained at baseline can predict future risk of cardiovascular adverse events, and to  determine if temporal changes in biomarker levels can provide a better risk prediction compared to biomarker assay obtained at baseline.

The purpose of this study is to assess operative and postoperative outcomes after aortic valve surgery, evaluate for changes in ascending aorta diameter by comparing pre-operative CT imaging to measurements on follow-up imaging, and examine late outcomes and functional status during the follow-up period with specific focus on mortality, need for re-operation and incidence of aortic dissection.