Clinical Trials

The purpose of this study is to compare the efficacy of a low-volume bowel preparation versus a high-volume bowel preparation for bowel cleansing on hospitalized patients undergoing colonoscopies.

The purpose of this study is to compare the effectiveness of Colon Capsule Endoscopy versus Computed Tomographic Colonography for the screening of colon polyps in the usual screening population.

The purpose of this study is to understand and assess patients’ current acceptability of machine learning/AI during colonoscopy for polyp detection.Our secondary aims are to determine what factors influence patients’ responses and to determine the various thresholds in adenoma detection rate (ADR) that would be acceptable to patients. 

This study first is designed to see what dose of indigo carmine ingested orally mixed with the standard colonoscopy prep is needed to provide adequate staining of the right colon. It then will use this adequate staining concentration of Indigo Carmine to study whether this dye will increase the detection of polyps during colonoscopy.

The purpose of this study is to understand how to improve polyp resection of large polyps, and how to make it as effective and as safe as possible.

The purpose is to investigate whether a simple additional treatment applied during colonoscopy (called 'soft' coagulation) can reduce the risk of recurrence of polyp at the area where the polyp was removed. After a large polyp is removed it is known that there is a 20% chance that a small recurrence of polyp occurs at the site of removal can occur within 5 months of the polyp being removed. This in theory will burn off tiny polyp tissue, which is usually not visible to the naked eye. This additional treatment may possibly reduce the risk of polyp recurrence.

Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States (1). Colorectal cancer arises from colonic polyps. The major types of polyps associated with colorectal cancer development are adenomatous (tubular which is most common and other types are villous and tubulovillous) and serrated (hyperplastic, sessile or traditional) polyps with varying degrees of dysplasia (2). Hyperplastic polyps are common but they have a low malignancy potential (3). There is evidence that colonic inflammation plays a major role in colon polyp and colorectal cancer development. For example, inflammatory bowel disease is a major ...

The purpose of this study is to see if advanced endoscopic imaging may be helpful to accurately distinguish pathological tissue from normal tissue and guide therapy of endoscopically identified pathology.

The purpose of this study is to form processes to get findings from targeted gene sequencing that can be acted on using two common actionable genetic disorders–familial hyperlipidemia and familial colorectal cancer. 

This is a proof-of-concept study to evaluate the preliminary clinical activity of guselkumab in subjects with Familial Adenomatous Polyposis. The study is designed to determine if guselkumab has clinical activity in the colorectum and duodenum, by reducing the number of polyps over a period of 24 weeks.