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A Study To Assess The Effectiveness And Safety Of Brensocatib In Participants With Non-Cystic Fibrosis Bronchiectasis
Jacksonville, FL
The purpose of this study is to evaluate the effect of brensocatib at 10 mg and 25 mg compared with placebo on the rate of pulmonary exacerbations (PEs) over the 52-week treatment period.
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A Phase II Study Of Ensifentrine In Non-Cystic Fibrosis Bronchiectasis
Rochester, MN
This study is a randomized, double-blind, placebo-controlled study designed to assess the efficacy and safety of ensifentrine inhalation suspension (3 mg) delivered twice daily via standard jet nebulizer over at least 24 weeks, compared to placebo, in subjects with non-cystic fibrosis bronchiectasis (NCFBE).
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Ciprofloxacin Dry Powder For Inhalation (DPI) In Non-cystic Fibrosis Bronchiectasis (Non-CF BE)
Rochester, MN
The purpose of this study is to evaluate if the time to first pulmonary exacerbation of bronchiectasis or its frequency can be prolonged by inhalation of ciprofloxacin for 28 days every other 28 days or for 14 days every other 14 days over 48 weeks.
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The AIRTIVITY™ Study: A Study To Find Out Whether BI 1291583 Helps People With Bronchiectasis
Jacksonville, FL; Rochester, MN
This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations).
The purpose of this study is to find out whether a medicine called BI 1291583 helps people with bronchiectasis. Participants are put into 2 groups randomly, which means by chance. One group takes BI 1291583 tablets and the other group takes placebo tablets. A placebo tablet looks like the BI 1291583 tablet but does not contain any medicine. Participants take 1 tablet once a day for up to 1 ...
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Home-based Pulmonary Rehabilitation and Health Coaching to Treat Bronchiectasis
Rochester, MN
The purpose of this study is to assess the effect-size of a novel combined home-based telemonitored pulmonary rehabilitation and telephonic health coaching program on two co-primary endpoints: 1) patient-reported quality of life as assessed by the COPD Assessment Test (CAT) and 2) physical activity (PA) as measured by steps per day.
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A Study Of Airway Mycobiome In Inflammation And Chronic Infections In Bronchiectasis
Rochester, MN
The purpose of this study is to investigate the relationship between inflammatory endotypes of NCFB and the airway mycobiome. We hypothesize that patients with EB, defined by an absolute eosinophil count >300 cells/uL at the time of respiratory sample collection, have a higher relative abundance of molds in their airways compared to NCFB patients with other inflammatory endotypes.