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Pretest of Alfapump® Patient Preference Discrete-choice Experiment
Scottsdale/Phoenix, AZ; Rochester, MN
The overall objective of the patient preference evaluation is to understand how patients tradeoff the benefits and risks of the alfapump related to the primary endpoints of the current POSEIDON clinical trial in support of future marketing application.
The alfapump system is designed to reduce or eliminate the need for therapeutic paracentesis and to provide relief from symptoms of tense ascites with its attendant effects on patient quality of life (QOL) and nutrition. fits and risks of the alfapump related to the primary endpoints of the current POSEIDON clinical trial in support of future marketing application.
Liver Ascites Patient Treatment Preferences of Implantable Devices
Rochester, MN; Scottsdale/Phoenix, AZ
The puropose of this study is to utilize a discrete-choice experiment (DCE) survey to elicit benefit-risk preferences for interventional treatment attributes in patients with refractory or recurrent ascites due to liver cirrhosis.
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A (M)Ulti-center, Prospective, (O)Pen Label, Uncontrolled Feasibility (S)Tudy To Assess The Safety And Effectiveness Of An Automatic Low Flow (A)Scites (Alfa) Pump (I)n Patients With (C)Irrhosis And Refractory Or Recurrent Ascites
Scottsdale/Phoenix, AZ; Rochester, MN
The study is a multi-center, prospective, open label, uncontrolled feasibility study enrolling 30 patients with refractory or recurrent ascites and cirrhosis at up to 6 sites. Patients will be enrolled during a 6 month enrollment phase after which data will be collected for 12months with an initial analysis after 3 months. Extended follow-up for safety monitoring purposes will continue for the lifetime of the patient or until the device is explanted.
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A Study Of OCE-205 In Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury
Scottsdale/Phoenix, AZ
The purpose of this study is to evaluate the safety and effectiveness of OCE-205 at various doses.
OCE-205 is being tested to treat participants who have developed Hepatorenal Syndrome-Acute Kidney Injury as a complication of cirrhosis with ascites.
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International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project
Rochester, MN
The purpose of this study is to identify the clinical characteristics, the management and the outcomes of acute kidney injury (AKI) in patients with cirrhosis worldwide. Additionally, to establish the severity of AKI across different regions, to identify precipitants of AKI across different centers, to identify the phenotypes of AKI across different centers, to evaluate differences in the management of AKI across different centers and their impact on clinical outcomes, and to assess outcomes of acute kidney injury (resolution of AKI, in-hospital mortality, 28-day mortality, 90-day mortality).