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A Study Of Ultrasound Assessment Of Diaphragmatic Function Following Liposomal Bupivacaine Administration For Interscalene Nerve Blocks

Overview

About this study

The purpose of this study is to determine if measuring diaphragm thickness via ultrasonography will show a decrease in muscle thickness on the ipsilateral side that a liposomal bupivacaine block was placed.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult patients (18 years of age and older) undergoing shoulder arthroplasty who have consented to interscalene blockade for postoperative analgesia.

 

Exclusion Criteria:

  • Patient refusal and contraindications of interscalene blockade due to patient factors such as: significant pulmonary insufficiency, pre-existing hemidiaphragmatic paralysis, brachial plexus or degenerative neuropathy, allergy to proposed local anesthetic medication, severe cervical spine disease, BMI >40 kg/m2, neck circumference >50cm, pre-existing thoracic/diaphragmatic operations, and failed preoperative interscalene blockade. Patient is unable to provide informed consent. Patient is pregnant. Patient pregnancy status will be obtained through standard of care at Mayo Clinic per Pre-Procedure Pregnancy Reasonably Excluded Guide (PREG) protocol

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 03/25/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Carlos Mantilla, M.D., Ph.D.

Contact us for the latest status

More information

Publications

Publications are currently not available

More about research at Mayo Clinic

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CLS-20612010

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