Clinical Trials

General Inclusion Criteria:

• Aged between 25 and 70 years of age

• Reside within a 100-mile radius of Mayo Clinic, Rochester, MN

Study Groups

• Group 1 (Obese + IFG): 

  • BMI > 28 Kg/M² and < 40 Kg/M²

  • Impaired Fasting Glucose (IFG – fasting glucose >100 but <126 mg/dL)

•  Group 2 (Control group/Lean):

  • BMI > 19 Kg/M² and < 25 Kg/M²

  • Fasting glucose < 100mg/dL

• Group 3 (T1DM):

  • BMI > 28 Kg/M² and < 40 Kg/M²

  • Type 1 diabetes (T1DM)

•  Group 4 (Obese + NFG) :

  • BMI > 28 Kg/M² and < 40 Kg/M²

  • Fasting glucose < 100mg/dL

General Exclusion Criteria:

• Age < 25 (to ensure that we are not studying subjects with latent type 1 diabetes as people in Olmsted County presenting before age 25 have a high incidence of T1DM) or > 70 years (to avoid extreme age as a factor in islet function).

• Use of any glucose-lowering agents.

• For female subjects: positive pregnancy test at the time of enrollment or study

• History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.

• Active systemic illness or malignancy.

• Symptomatic macrovascular or microvascular disease.

Study Groups

• Group 1 (Obese + IFG): 

  • BMI < 28 Kg/M² or > 40 Kg/M²

  • HbA_1c > 6.5% or fasting glucose < 100mg/dL or > 126 mg/dL

• Group 2 (Control group/Lean):

  • BMI < 19 Kg/M² or > 25 Kg/M²

  • HbA_1c > 5.8% or fasting glucose > 100mg/dL

• Group 3 (T1DM):

  • BMI < 28 Kg/M² or > 40 Kg/M²

  • HbA_1c < 5.8 or > 9.0%

• Group 4 (Obese + NFG):

• BMI < 28 Kg/M² or > 40 Kg/M²

• HbA_1c > 5.8% or fasting glucose > 100mg/dL

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 07/29/2026. Questions regarding updates should be directed to the study team contact.