Clinical Trials

Inclusion Criteria:

• Age 18 years or older

• Cognitively normal, defined as: no subjective cognitive complaints, and normal performance on brief standardized cognitive screening or semi-structured assessment of cognitive function (i.e., the Clinical Dementia Rating [CDR®]).

• Neurologically normal on the examination performed by a study clinician at enrollment

• Willing and able to provide written informed consent

• Willing to undergo a single lumbar puncture and blood draw for research

Exclusion Criteria:

• Any current neurological diagnosis or history of significant neurological disease (including dementia, epilepsy, stroke, multiple sclerosis, Parkinson’s disease, or other CNS disorder)

• Active anticoagulation therapy (and unable to hold for the procedure), known clotting disorder, or abnormal coagulation studies on safety labs

• Active systemic or CNS infection

• History of significant traumatic brain injury

• Thrombocytopenia (platelet count < 50,000/µL) or other hematological contraindication to LP

• Anatomical abnormality of the lumbar spine that would preclude safe LP in the opinion of the performing physician

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 05/07/2026. Questions regarding updates should be directed to the study team contact.