Clinical Trials

Inclusion Criteria:

• Age, 60 and older

• Prescribed GLP-1 RA medication in the Clinic

Exclusion Criteria:

• MSSE score < 24

• BMI >55 kg/m² (for practical considerations related to the difficulty in obtaining muscle biopsies and successfully inserting IV catheters in this patient population, based on current experiences)

• Supplements affecting protein metabolism

• Diabetes

• Presence of acute illness

• Renal disease (due to potential confounding effects on muscle protein metabolism)

• Congestive heart failure

• Low hemoglobin or hematocrit

• Use anabolic steroids or corticosteroids

• Not classified as inactive/sedentary based on the Stanford Brief Activity Survey  and accelerometry data (i.e., sedentary/energy expenditure corresponding to ≤1.5 METs

• Currently on a weight loss intervention or planning to undertake a weight loss intervention (besides GLP-1 RAs)

• Smoking

• Gastro-intestinal surgery

• Cannot abstain from use of anticoagulants and medications such as aspirin, coumadin, plavix

• Any other condition or event considered exclusionary by the Investigators/Study Physician.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/01/2026. Questions regarding updates should be directed to the study team contact.