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A Study Of Defining And Targeting Epigenetic Vulnerabilities In CN-High Endometrial Cancer

Overview

About this study

The purpose of this study is to determine the feasibility of generating viable, expandable patient-derived organoids from prospectively collected benign endometrial tissue and high-grade endometrial cancer surgical specimens.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Group 1 Inclusion Criteria:  

  • Women age ≥ 18 years

  • Biopsy demonstrating benign endometrium with no evidence of endometrial intraepithelial neoplasia (EIN), atypical hyperplasia, or malignancy

  • Scheduled to undergo hysterectomy at Mayo Clinic for a benign gynecologic indication

  • Willing and able to provide signed informed consent

 

Group 2 Exclusion Criteria: 

  • Endometrial biopsy demonstrating EIN or malignancy

  • Planned hysterectomy is canceled or performed outside Mayo Clinic

 

Group 2 Inclusion Criteria:  

  • Women age ≥ 18 years

  • Biopsy-proven high-grade endometrial cancer

  • Biopsy histology is Grade 3 endometrioid, serous, clear cell, carcinosarcoma (MMMT), poorly differentiated, or undifferentiated

  • If newly diagnosed, scheduled to undergo hysterectomy at Mayo Clinic

  • Willing and able to provide signed informed consent

 

Group 2 Exclusion Criteria: 

  • Biopsy histology is Grade 1 or Grade 2 endometrioid

  • Receipt of neoadjuvant chemotherapy

  • Planned hysterectomy is canceled or performed outside Mayo Clinic

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 08/14/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Shariska Harrington, M.D.

Open for enrollment

More information

Publications

Publications are currently not available

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CLS-20610264

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