Functional Validation Of Mass Spectrometry–Identified Candidate Antigen Targets Using Primary Human T-cell Models

Overview

About this study

The purpose of this study is to generate expanded antigen-specific T-cell populations from healthy donor peripheral blood mononuclear cells (PBMCs) to serve as functional models of HLA-restricted immune recognition.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Age 18 years or older.
Able and willing to provide informed consent.
Willing to be contacted for additional, optional blood draw(s) if needed.

Exclusion Criteria:

History of malignancy that, in the investigator’s judgment, could affect immune function or study assay interpretation (e.g., hematologic malignancy such as multiple myeloma)
History of autoimmune or chronic inflammatory disease that could affect immune assays.
Current or recent (within 3 months) use of systemic immunosuppressive therapy.
Known blood-borne infectious disease (e.g., HIV, hepatitis B or C) per donor screening/medical history
Any condition that, in the investigator’s judgment, makes blood draw unsafe or could significantly affect immune assay interpretation.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 07/06/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Akhilesh Pandey, M.D., Ph.D.	Open for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Akhilesh Pandey, M.D., Ph.D.

Open for enrollment

More information

Publications

Publications are currently not available

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