MerCuRE Study

Overview

About this study

1.      Patient Reported Outcomes (PRO’s) including:

a.      KOOS score (The Knee Injury and Osteoarthritis Outcome Score).

b.      Marx activity rating scale for patients > 18 years old.

c.       Pedi-FABS score (Pediatric Functional Activity Brief Scale) for patients 10-18 years old.

d.      Western Ontario Meniscal Evaluation Tool (WOMET) score

 

2.      Data on Failure: defined as removal of the whole or large proportion of the graft (total or subtotal meniscectomy or a large irreparable radial tear), conversion to arthroplasty or revision of the Meniscal Transplant.

 

3.      Serial Imaging including radiographs, ultrasound (US), and magnetic resonance imaging (MRI) to determine the graft longevity, status/presence of extrusion and the post-operative chondral status of the knee.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

1.      Males and females aged 10-65 years.

2.      MRI or arthroscopic images confirming the suitability for meniscus transplantation. Focal chondral defects that are suitable for resurfacing or small enough to be ignored will be included provided there is a general preservation of cartilage in the joint.

3.      Patients undergoing an isolated primary/revision MAT procedure, or concomitant MAT with other knee procedures such as ligament reconstruction, realignment osteotomy, or cartilage resurfacing.

4.      Medically suitable for meniscus transplantation.

5.      Appropriate understanding of the language of the surgical center in terms of communication and reading.

6.      Ability of the Patient or parent/guardian to provide informed consent.

 

Exclusion Criteria:

1.      Patient aged less than 10 years and more than 65.

2.      Presence of diffuse full thickness cartilage loss (widespread ICRS Grade III-IV chondral damage) and/or architectural remodeling of bone (i.e. flattening of condyle) in the knee of interest.

3.      Significant medical comorbidities that limit patients from undergoing surgery.

4.      Presence of confounding neuromuscular, genetic/congenital, or post-traumatic conditions.

5.      Inability to comply with rehabilitation programs.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Aaron Krych, M.D.

Open for enrollment

Contact information:

Craig Konwinski

5072558388

konwinski.craig@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20609542

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