Clinical Trials

Inclusion Criteria:

• Age 18 years or older

• Prior kidney biopsy showing thin basement membrane nephropathy/thin basement membrane findings, as documented in the medical record or pathology report

• Persistent microscopic hematuria, with or without proteinuria, documented in the medical record

• Prior clinical genetic testing using the 385-gene targeted nephropathy exome panel

• Prior 385-gene targeted nephropathy exome panel result was negative or non-diagnostic

• Able and willing to provide informed consent

• Able and willing to provide a DNA sample using a mailed collection kit

Exclusion Criteria:

• Younger than 18 years of age

• No prior 385-gene targeted nephropathy exome panel testing

• Prior 385-gene targeted nephropathy exome panel identified a diagnostic positive result that explains the renal phenotype

• No documented persistent microscopic hematuria

• No biopsy-proven thin basement membrane nephropathy/thin basement membrane finding

• Unable to provide informed consent at the time of enrollment

• Prisoner or individual under supervised correctional custody

• Unable or unwilling to provide a DNA sample using the mailed collection kit

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 06/23/2026. Questions regarding updates should be directed to the study team contact.