Clinical Trials

Inclusion Criteria:

• Patients meeting the Sepsis-3 definition of sepsis or septic shock⁴ (index and readmission) and being treated with an institutional, evidence-based guideline management bundle for sepsis within 24 hrs. The sequential organ failure assessment (SOFA) score will be used for organ failure assessment.

Exclusion Criteria:

• Alternative/confounding diagnosis causing shock (e.g., myocardial infarction or pulmonary embolus)

• Uncontrollable source of sepsis (e.g., irreversible disease state such as unresectable dead bowel)

• Advanced directives limiting resuscitative efforts

• Organ transplant recipient on immunosuppressive agents

• Known pregnancy

• Inability to obtain informed consent

• HIV/AIDS with CD4 count < 200

• Absolute neutrophil count < 500

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 03/04/2026. Questions regarding updates should be directed to the study team contact.