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A Study Of Beta-Trace Protein And Beta-2 Transferrin In Middle Ear Effusions

Overview

About this study

The purpose of this study is to understand the range of values of Beta-2 trace protein concentrations in middle ear effusions of patients with and without concern for lateral skull base cerebrospinal fluid leaks.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 16 years or older; middle ear effusion meeting criteria for offering myringotomy or myringotomy and tympanostomy tube or chronic otorrhea raising clinical concern for cerebrospinal fluid leak; must desire myringotomy or tympanostomy tube for management of their symptoms or to evaluate for a cerebrospinal fluid leak

 

Exclusion Criteria: 

  • Patients who would not otherwise be offered a myringotomy or myringotomy with tympanostomy tube for management of their symptoms

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 03/30/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Mallory Raymond, M.D.

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Rochester, Minn.

Mayo Clinic principal investigator

James Dornhoffer, M.D.

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More information

Publications

Publications are currently not available

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CLS-20602651

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