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Complex Adult Deformity Surgery (CADS)

Overview

About this study

Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Criteria:

Inclusion Criteria:

  1. Diagnosis of adult congenital, degenerative, idiopathic or iatrogenic spinal deformity

  2. Full body EOS radiographic assessment (sagittal and coronal visualization from skull to foot)

  3. Complex patients are defined as and meeting any one of the subsequent criteria:

    1. Radiographic criteria:

      • PI-LL ≥ 25 degrees

      • TPA ≥ 30 degrees

      • SVA>15cm

      • Thoracic scoliosis ≥ 70 degrees

      • Thoracolumbar/lumbar scoliosis ≥ 50 degrees

      • Global coronal malalignment >7cm

    2. Procedural criteria:

      • Posterior spinal fusion > 12 levels

      • 3 column osteotomy or ACR

    3. Geriatric criteria:

      • Age >65 years and minimum 7 levels of spinal instrumentation during surgery

Exclusion Criteria:

  1. Age <18 years of age

  2. Active spine tumor or infection

  3. Deformity due to acute trauma

  4. Neuromuscular conditions/diseases (Parkinson's, Multiple Sclerosis, Post-polio syndrome)

  5. Syndromic scoliosis

  6. Inflammatory arthritis/auto immune diseases (Rheumatoid arthritis, Lupus, Ankylosing Spondylitis)

  7. Prisoners

  8. Women who are pregnant

  9. Non English speaking patients

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/21/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Anthony Mikula, M.D.

Contact us for the latest status

Contact information:

Justice Story

5074225528

story.justice@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20600282

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