A Study Of Fatty Infiltration Of The Opponens Pollicis Muscle And Symptomatic Thumb Carpometacarpal

Overview

About this study

The purpose of this study is to evaluate the association of thumb carpometacarpal (CMC) arthritis and fatty infiltration (FI) of the opponens pollicis muscle with hand symptoms as measured by the Visual Analog Scale (VAS) for Pain and the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Subjects 18 years or older with a wrist MRI showing thumb CMC arthritis and/or opponens FI, providing consent to complete questionnaires.

Exclusion Criteria:

Thumb fractures, wrist fractures or penetrating thumb trauma in the last 6 months. Carpal tunnel syndrome with abnormal motor tests, on electrodiagnostic testing (motor latency or amplitude changes or abnormal EMG). Active inflammatory arthritis (such as rheumatoid, lupus, or psoriatic arthritis). Inability to give consent or complete questionnaires.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 02/04/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Peter Amadio, M.D.	Open for enrollment	Contact information: Jenny Obst 5072843382 obst.jenny@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Peter Amadio, M.D.

Open for enrollment

Contact information:

Jenny Obst

5072843382

obst.jenny@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials