Clinical Trials

Inclusion Criteria:  

• 18 or older with full capacity to make decisions

• Undergoing non-emergent cervical, thoracic, or lumbar spine surgery

• No compressive myelomalacia on MR imaging

• No history of limb amputation

Exclusion Criteria: 

• [Baseline neurologic exam] Preoperative exam worse than -1 strength on Mayo rating scale (or worse than 4+/5 on the Medical research council strength scale) for the monitored muscles

• [Determined in OR, anesthesia compatibility] Anesthesia need for use of dexmedetomidine, inhalational anesthetics, or neuromuscular blockade at time of baseline signal acquisition (a short course of these drugs at time of intubation is acceptable)

• [determined in OR: MEP reliability] Upon best optimization with either bipolar or LQP, tcMEP response from at least one muscle among left and right abductor digiti minimi, tibialis anterior, or abductor hallucis, at time of baseline is any of the following:

  • < 1000 μV*ms area under the curve

  • Qualitatively high trial-to-trial variability on visual inspection

  • Absent or only inconsistently present

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 04/06/2026. Questions regarding updates should be directed to the study team contact.