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A Study Of Whole Exome Sequencing Of Total Joint Arthroplasty Patients

Overview

About this study

The purpose of this study is to identify the frequency of genetic mutations in patients who developed a VTE after a total hip or total knee arthroplasty.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Primary total hip or knee arthroplasty patient

  • Age >18 years old

  • Confirmed venous thromboembolism (VTE) (symptomatic deep vein thrombosis [DVT] or pulmonary embolism [PE]) within 6 months from index surgical date.

 

Exclusion Criteria: 

  • Revision total joint arthroplasty or reoperation for initial primary total knee arthroplasty (For example: irrigation and debridement with implant retention)

  • Non-elective indications for arthroplasty (oncologic and fracture related)

  • History of prior VTE

  • Active pharmacologic treatment for coagulopathy

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

 

Eligibility last updated 10/20/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Bryan Springer, M.D.

Contact us for the latest status

Contact information:

Lauren Evans

evans.lauren2@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20598550

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